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Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy

NCT ID: NCT06152939

Last Updated: 2023-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2024-12-31

Brief Summary

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• to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary intervention (PPCI) , or thrombolytic therapy .

Detailed Description

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ST-segment elevation myocardial infarction (STEMI) has been associated with a high rate of morbidity and mortality (1) Left ventricular thrombus (LVT), one of the most common complications of acute anterior myocardial infarction is linked to the potentially devastating outcome of thromboembolism or stroke \[1, 2\] , In the era of primary PCI, despite aggressive reperfusion treatment and antithrombotic treatment, the presence of LVT remains high after anterior STEMI), Determining the correlation between clinical and laboratory indicators of thrombosis is the key to the prevention of thromboembolism , The PLR( platelets to lymphocytes ratio ), a new index , provides information about both the inflammatory and thrombosis pathways(3), It is known since long that larger platelets are metabolically and enzymatically more active than small platelets and they have higher thrombotic potentials , that is why MPV , Platelets count , and platelet crit (PCT) are related to platelets activation and they have been suggested as markers of haemostasis , Increase MPV is thought to be associated with thrombus formation in all vascular structures , Recent evidence has shown the meaningful clinical information of the PLR in coronary heart disease and thrombotic diseases (whether diagnostic information or prognostic information). Despite the findings above, data regarding the role of this inflammatory biomarker in LVT are lacking. We conducte a prospective case-control study to explore the correlation between LVT and the PLR and different hematologic indices among anterior STEMI patients with LV dysfunction after primary PCI, or thromolytic therapy, Hematological markers, predictive and even diagnostic value in cardiovascular diseases (CVDs) is a major field of research (4) Leukocytes are considered essential for thrombus formation as well as plaque activation in acute coronary syndrome (ACS). The most reliable indicator of unfavorable outcomes has been proven to be platelet count and may platelet volume, haematocrit, haemoglobin, peak level Troponin and CK-MB (5), Monocytes play a critical role in atherosclerosis by releasing cytokines that are pro-inflammatory and pro-oxidant (6) High values of the monocyte are associated with unfavourable outcomes and severe coronary artery disease (7) ). So, we aimed to find relationship between the different hematological indices and LV thrombus formation in anterior STEMI managed by primary percutaneous coronary intervention (PPCI) or thrombolytic therapy.

Conditions

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Left Ventricular Thrombus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

patients with acute anterior ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention .

Primary percutaneous coronary intervention or thrombolytic therapy

Intervention Type OTHER

Primary percutaneous coronary intervention or thrombolytic therapy

2

patients with acute anterior ST segment elevation myocardial infarction have thrombolytic therapy .

Primary percutaneous coronary intervention or thrombolytic therapy

Intervention Type OTHER

Primary percutaneous coronary intervention or thrombolytic therapy

Interventions

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Primary percutaneous coronary intervention or thrombolytic therapy

Primary percutaneous coronary intervention or thrombolytic therapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients presented to Assiut university cardiac catheterization laboratory with acute anterior STEMI and managed with PPCI or thrombolytic therapy.

Exclusion Criteria

* • Patients not eligible to PPCI

* Patients presented with inferior or lateral STEMI or any type of STEMI other than anterior STEMI.
Minimum Eligible Age

15 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Al zahraa Sayed Mahmoud Mohamed

Relation of laboratory indices to left ventricular thrombus formation in patients with acute anterior ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention or thrombolytic therapy

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Al zahraa Sayed

Role: CONTACT

Phone: 01015692124

Email: [email protected]

Yehia Kishk

Role: CONTACT

Phone: 01223971269

Email: [email protected]

Related Links

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https://www.google.com/search?q=Chacon-Diaz+M%2C+Custodio&rlz=1C1RLNS_enEG1029EG1029&oq=Chacon-Diaz+M%2C+Custodio&aqs=chrome..69i57j33i10i160.56552j0j15&sourceid=chrome&ie=UTF-8

Related Info

https://www.google.com/search?q=vogel+b+claessen+e+arnold+v+et+al+2019%29&sca_esv=566650974&rlz=1C1RLNS_enEG1029EG1029&ei=NNwJZdGRNeKrkdUPq8uu4Ak&oq=Vogel+B%2C+Claessen+E%2C+Arnold+V+et+al+2019&gs_lp=Egxnd3Mtd2l6LXNlcnAiKFZvZ2VsIEIsIENsYWVzc2VuIEUsIEFybm9sZCBWIGV0IGFsIDIwMTkqAggAMgUQIRigAUisnAhQsPYBWL-UB3AFeACQAQGYAcYDoAGyO6oBCjAuMzYuNC4xLjG4AQHIAQD4AQGoAgDCAgsQABiABBixAxiDAcICERAuGIAEGLEDGIMBGMcBGNEDwgIIEAAYgAQYsQPCAgsQLhiKBRixAxiDAcICBRAAGIAEwgIOEC4YgAQYsQMYxwEY0QPCAg0QLhiKBRjHARjRAxhDwgIgEC4YgAQYsQMYgwEYxwEY0QMYlwUY3AQY3gQY4ATYAQHCAg0QABiKBRixAxiDARhDwgILEC4YgAQYxwEY0QPCAgUQLhiABMICCxAuGIAEGMcBGK8BwgIUEC4YgAQYlwUY3AQY3gQY3wTYAQHCAgYQABgWGB7CAgkQABgWGB4Y8QTCAggQIRgWGB4YHcICBxAhGKABGArCAgQQIRgVwgIFEAAYogTiAwQYACBBiAYBugYGCAEQARgU&sclient=gws-wiz-serp

Related Info

https://www.google.com/search?q=kumar+v+sharma+k+kumar+t+2020+pdf&sca_esv=566650974&rlz=1C1RLNS_enEG1029EG1029&ei=ct8JZfnjGP2ikdUPnOCb6Aw&oq=Kumar+V%2C+sharma+K+%2CKumar+T+2020&gs_lp=Egxnd3Mtd2l6LXNlcnAiH0t1bWFyIFYsIHNoYXJtYSBLICxLdW1hciBUIDIwMjAqAggAMgcQIRigARgKSK-6BVDADli-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_CAggQIRgWGB4YHcICChAhGBYYHhgPGB3CAgQQIRgV4gMEGAEgQYgGAboGBggBEAEYFA&sclient=gws-wiz-serp

Related Info

Other Identifiers

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LV thrombus in anterior STEMI

Identifier Type: -

Identifier Source: org_study_id