Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients

NCT ID: NCT03899389

Last Updated: 2019-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-01

Study Completion Date

2018-05-31

Brief Summary

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The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.

The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.

Detailed Description

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To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.

Conditions

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Coronary Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Acute Coronary Syndrome (ACS)

Patients with STEMI or NSTEMI infarction, who were admitted to the hospital with chest pain.

plasma samples collection

Intervention Type DIAGNOSTIC_TEST

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Stable Angina (SA)

Patients with stable angina who were scheduled for conventional coronary angiography.

plasma samples collection

Intervention Type DIAGNOSTIC_TEST

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Control Group (CON)

Healthy control group responding by age and gender to examined groups.

plasma samples collection

Intervention Type DIAGNOSTIC_TEST

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Interventions

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plasma samples collection

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* diagnosed stable angina (SA) or acute coronary syndrome (ACS) and planned coronography

Exclusion Criteria

* unconscious patient
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Gdansk University of Physical Education and Sport

OTHER

Sponsor Role lead

Responsible Party

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Robert Olek

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Robert A Olek, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Physical Education and Sport in Gdansk

Locations

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University of Physical Education and Sport

Gdansk, Pomeranian Voivodeship, Poland

Site Status

Countries

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Poland

Other Identifiers

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DSRiK/10/2018

Identifier Type: -

Identifier Source: org_study_id

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