A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling

NCT ID: NCT03884231

Last Updated: 2024-11-20

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-10

Study Completion Date

2021-08-20

Brief Summary

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The Infinity MRI PMCF was conducted as an international, multicenter, observational, prospective, single-arm, post-market clinical follow-up (PMCF) study. The study evaluated the safety of the Infinity DBS system with MR Conditional labeling when an MRI procedure was performed according to the approved guidance. Subjects were followed for 1 month after the MRI procedure. Participation in the clinical study ended at the conclusion of the 1-month follow-up visit where subjects were then followed per standard of care.

Detailed Description

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Conditions

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Movement Disorders Parkinson Disease Essential Tremor Tremor Dystonia

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Infinity DBS System with MR Conditional labelling

The Infinity DBS system with MR Conditional labelling includes a primary cell implantable pulse generator designed to deliver low-intensity electrical pulses to targeted structures in the brain.

Infinity DBS System with MR Conditional labelling

Intervention Type DEVICE

Patients implanted with the Infinity DBS system with MR Conditional labeling

Interventions

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Infinity DBS System with MR Conditional labelling

Patients implanted with the Infinity DBS system with MR Conditional labeling

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subject or subject's legally acceptable representative must provide written informed consent prior to any clinical investigation related procedure.
2. Subject has been implanted, or is scheduled to be implanted, with a commercially available Infinity DBS system with MR Conditional labeling per locally approved indications for use.
3. Subject is scheduled to undergo a MRI procedure in compliance with the MRI Procedure Information Clinician's Manual. Anxiolytics and patient's regular medications may be administered, provided Instructions For Use (IFU) criteria are met.
4. Subject is willing and able to comply with study requirements.

Exclusion Criteria

1. Subject has another implanted device (active or passive implanted device) that prohibits safe scanning.
2. Subject has previously experienced an MRI-related adverse event or cannot undergo MRI for any other reason.
3. Subject is pregnant or nursing, or plans to become pregnant during the clinical investigation follow-up period.
4. Subject has other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results.
5. Subject is currently participating in another clinical investigation that may confound the results of this study.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Binith Cheeran

Role: STUDY_DIRECTOR

Abbott Medical Devices Neuromodulation

Locations

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Banner University Medical Center Tucson Campus

Tucson, Arizona, United States

Site Status

University of Colorado Hospital

Aurora, Colorado, United States

Site Status

Neurosurgery One

Littleton, Colorado, United States

Site Status

Emory University Hospital

Atlanta, Georgia, United States

Site Status

Willis-Knighton Medical Center

Shreveport, Louisiana, United States

Site Status

Robert Wood Johnson University Hospital

New Brunswick, New Jersey, United States

Site Status

Wright State University & Premier Health

Fairborn, Ohio, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Inland Northwest Research

Spokane, Washington, United States

Site Status

CHU Gabriel Montpied

Clermont-Ferrand, Auverg N, France

Site Status

Universitäts Klinikum Tübingen

Tübingen, Bad-wur, Germany

Site Status

Medizinische Einrichtungen der Universität Düsseldorf

Düsseldorf, N. RHIN, Germany

Site Status

Universitatsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, Rhinela, Germany

Site Status

Hospital Universitario de la Princesa

Madrid, , Spain

Site Status

Universitetsjukhuset I Lund

Lund, Skåne County, Sweden

Site Status

Akademiska sjukhuset

Uppsala, Uppland, Sweden

Site Status

Countries

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United States France Germany Spain Sweden

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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ABT-CIP-10262

Identifier Type: -

Identifier Source: org_study_id

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