"Impact of Pelvic Floor Prehabilitation Using Biofeedback on the Severity of the Low Anterior Resection Syndrome in Patients Undergoing a Total Mesorectal Excision for Rectal Cancer"

NCT ID: NCT03876561

Last Updated: 2020-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-27

Study Completion Date

2022-05-31

Brief Summary

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There is currently no specific treatment and only few measures to prevent the low anterior resection syndrome (LARS). The LARS often results in a severe alteration of quality of life. This study is designed to assess pelvic floor prehabilitation using biofeedback in the prevention of LARS following total mesorectal excision for cancer. The pelvic floor rehabilitation with biofeedback has already been tested postoperatively in patients suffering from LARS with heterogeneous results. However, this rehabilitation has never been evaluated in the prevention of LARS.

The prehabilitation is an innovative concept currently evaluated in the prevention of functional complications following orthopedic surgery and also prostate surgery. In high-risk abdominal surgery, cardiopulmonary prehabilitation offers satisfying results in terms of morbidity and mortality rates. This study will be the first to assess pelvic floor prehabilitation in the prevention of LARS.

Detailed Description

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Conditions

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Rectal Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Prehabilitation

The systematic pelvic floor prehabilitation will start 4 weeks before stoma closure and will include 1 sessions per week before stoma closure and 1 sessions per week during 6 weeks following stoma closure. Complementary sessions are allowed if necessary.

Group Type EXPERIMENTAL

Pelvic floor prehabilitation

Intervention Type PROCEDURE

The systematic pelvic floor prehabilitation will start 4 weeks before stoma closure and will include 1 session per week before stoma closure and 1 session per week during 6 weeks following stoma closure. The prehabilitation will be performed according to a predefined protocol based on a biofeedback strategy.

No intervention

No pelvic floor prehabilitation will be proposed before stoma closure. The pelvic floor prehabilitation will be proposed to patients suffering from LARS

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Pelvic floor prehabilitation

The systematic pelvic floor prehabilitation will start 4 weeks before stoma closure and will include 1 session per week before stoma closure and 1 session per week during 6 weeks following stoma closure. The prehabilitation will be performed according to a predefined protocol based on a biofeedback strategy.

Intervention Type PROCEDURE

Other Intervention Names

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Preoperative rehabilitation

Eligibility Criteria

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Inclusion Criteria

* Age between 18 and 80 years old
* Total mesorectal excision with colorectal or coloanal anastomosis protected by an ileostomy or a colostomy for rectal cancer
* Absence of anastomotic leakage or stenosis
* Informed consent to participate in the study
* Social security insurance affiliation

Exclusion Criteria

* History of anal incontinence and/or fecal urgency and/or chronic diarrhea requiring a specific treatment before rectal cancer management
* Absence of ileostomy or colostomy
* Anastomotic leakage
* Sensorial or cognitive disorders impeding pelvic floor rehabilitation exercise
* Pregnant women
* Minors
* Adults under guardianship
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Angers

Angers, , France

Site Status RECRUITING

APHP-Hôpital Beaujon

Clichy, , France

Site Status NOT_YET_RECRUITING

CHD Vendée

La Roche-sur-Yon, , France

Site Status RECRUITING

Clinic Jules Verne

Nantes, , France

Site Status NOT_YET_RECRUITING

CHU de Poitiers

Poitiers, , France

Site Status RECRUITING

CHU de Tours

Tours, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Guillaume MEURETTE

Role: CONTACT

0240083027

Emilie DUCHALAIS

Role: CONTACT

0240084322

Facility Contacts

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Antoine Hamy

Role: primary

Yves Panis

Role: primary

Eric Abet

Role: primary

Jean-Michel Balon

Role: primary

Marie-Line Barussaud

Role: primary

Mehdi Ouaissi

Role: primary

References

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Alexandra P, Noemie P, Solene SB, Jean-Benoit H, Riche VP, Odile C, Michel G, Guy V, Hamy A, Mehdi O, Yannick T, Jeremie H L, Amar A, Emeric A, Jean-Michel B, Bridoux V, Dumont F, June F, Alexandra J, Meurette G, Duchalais E. Evaluation of pelvic floor rehabilitation in the prevention of low anterior resection syndrome: Study protocol of the CONTICARE trial. Colorectal Dis. 2025 Mar;27(3):e70045. doi: 10.1111/codi.70045.

Reference Type DERIVED
PMID: 40055837 (View on PubMed)

Other Identifiers

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RC16_0459

Identifier Type: -

Identifier Source: org_study_id

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