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Long-term Outcomes and Prognostic Factors in Patient Undergoing CABG or PCI

NCT ID: NCT03870815

Last Updated: 2023-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

10000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-27

Study Completion Date

2026-02-28

Brief Summary

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1. To evaluate the long-term clinical outcomes and prognostic factors in patients with coronary artery disease undergoing coronary artery bypass graft surgery.
2. To evaluate the long-term clinical outcomes and prognostic factors in patients with coronary artery disease undergoing percutaneous coronary intervention with drug-eluting stent.

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Detailed Description

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Coronary artery disease (CAD) still remains one of the world's leading causes of death, despite markedly improvement of devices and technologies on past several decades. The treatment strategy for CAD included medical treatment, percutaneous coronary intervention (PCI), and coronary-artery bypass grafting (CABG). CABG is a procedure in which autologous arteries or veins are used as grafts to bypass coronary arteries that are partially or completely obstructed by atherosclerotic plaque. During the past decade, there has been nearly a 30% decline in CABG procedures, despite abundant evidence to support the effectiveness and safety of the operation.This decline has been accompanied by a corresponding increase in PCI. To date, there have been numerous studies to compare the clinical outcomes between PCI and CABG for patients with CAD. Among them, SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) trial demonstrated CABG is associated with lower incidence of major adverse cardiac and cerebrovascualr events in patients with high SYNTAX score, compared with PCI. In this regard, the current guidelines recommend that CABG is preferred method for care of stable ischemic heart disease patients with three-vessel or left main coronary artery disease. However, most randomized controlled studies do not reflect the contemporary practice, because they have been performed in the era of bare metal stents or first-generation drug-eluting stent (DES). In addition, there have been limited data regarding the prognostic factors for long-term clinical outcomes in patients undergoing PCI with DES or CABG. Therefore, the investigators sought to compare the clinical outcomes between PCI with DES or CABG, and to identify prognostic factors for long-term clinical outcomes in patients who underwent PCI with DES or CABG.

Conditions

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Ischemic Heart Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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CABG

Patients with CAD who undergoing CABG

CABG

Intervention Type PROCEDURE

Patients who undergoing CABG

PCI

Patients with CAD who undergoing PCI with DES

PCI

Intervention Type PROCEDURE

Patients who undergoing PCI with DES

Interventions

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CABG

Patients who undergoing CABG

Intervention Type PROCEDURE

PCI

Patients who undergoing PCI with DES

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who suspected ischemic heart disease and underwent CABG or PCI with DES

Exclusion Criteria

* Age \< 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Young Bin Song

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Young Bin Song, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Young Bin Song, MD, PhD

Role: CONTACT

[email protected]
82-2-3410-3419

Ki Hong Choi, MD

Role: CONTACT

[email protected]
82-10-8875-1648

Facility Contacts

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Young Bin Song, MD, PhD

Role: primary

[email protected]
82-10-3410-3419

Ki Hong Choi, MD

Role: backup

[email protected]
82-10-8875-1648

References

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Lee SY, Cho YH, Sung K, Kim WS, Lee SJ, Kwon W, Lee JY, Lee SH, Shin D, Lee SY, Kim SM, Yun KH, Cho JY, Kim CJ, Ahn HS, Nam CW, Yoon HJ, Park YH, Lee WS, Choi KH, Park TK, Yang JH, Choi SH, Gwon HC, Song YB, Hahn JY, Jeong DS, Lee JM. Intravascular Imaging-Guided PCI vs Coronary Artery Bypass Grafting for Left Main or 3-Vessel Disease. JACC Cardiovasc Interv. 2025 Sep 8;18(17):2077-2088. doi: 10.1016/j.jcin.2025.06.034. Epub 2025 Aug 27.

Reference Type DERIVED
PMID: 40864021 (View on PubMed)

Lee SY, Lee SJ, Kwon W, Lee SH, Shin D, Lee SY, Kim SM, Yun KH, Cho JY, Kim CJ, Ahn HS, Nam CW, Yoon HJ, Park YH, Lee WS, Choi KH, Park TK, Yang JH, Choi SH, Gwon HC, Song YB, Hahn JY, Lee JY, Lee JM, Investigators TR. Outcomes of intravascular imaging-guided percutaneous coronary intervention according to lesion complexity. EuroIntervention. 2025 Feb 3;21(3):e171-e182. doi: 10.4244/EIJ-D-24-00755.

Reference Type DERIVED
PMID: 39901632 (View on PubMed)

Lee SH, Jo J, Yang JH, Kim SM, Choi KH, Song YB, Jeong DS, Lee JM, Park TK, Hahn JY, Choi SH, Chung SR, Cho YH, Sung K, Kim WS, Gwon HC, Lee YT. Clinical Impact of Sarcopenia Screening on Long-Term Mortality in Patients Undergoing Coronary Bypass Grafting. J Cachexia Sarcopenia Muscle. 2024 Dec;15(6):2842-2851. doi: 10.1002/jcsm.13645. Epub 2024 Nov 8.

Reference Type DERIVED
PMID: 39513369 (View on PubMed)

Joh HS, Kwon W, Shin D, Lee SH, Hong YJ, Hong D, Lee SY, Park H, Kim S, Lee SY, Koh JS, Kim H, Kim CJ, Choo EH, Yoon HJ, Park SD, Jeon KH, Bae JW, Ahn SG, Kim SE, Choi KH, Park TK, Yang JH, Song YB, Hahn JY, Choi SH, Gwon HC, Lee JM. Drug-Coated Balloon Angioplasty in Patients Undergoing Complex Percutaneous Coronary Intervention. JACC Asia. 2024 Jun 18;4(7):519-531. doi: 10.1016/j.jacasi.2024.04.007. eCollection 2024 Jul.

Reference Type DERIVED
PMID: 39101114 (View on PubMed)

Kwon W, Hong D, Choi KH, Lee SH, Shin D, Lee JY, Lee SJ, Lee SY, Kim SM, Yun KH, Cho JY, Kim CJ, Ahn HS, Nam CW, Yoon HJ, Park YH, Lee WS, Park TK, Yang JH, Choi SH, Gwon HC, Song YB, Hahn JY, Lee JM; RENOVATE-COMPLEX-PCI Investigators. Intravascular Imaging-Guided Percutaneous Coronary Intervention Before and After Standardized Optimization Protocols. JACC Cardiovasc Interv. 2024 Jan 22;17(2):292-303. doi: 10.1016/j.jcin.2023.10.062.

Reference Type DERIVED
PMID: 38267144 (View on PubMed)

Jang WJ, Choi KH, Kim J, Yang JH, Hahn JY, Choi SH, Gwon HC, Cho YH, Sung K, Kim WS, Jeong DS, Song YB. Impact of gender on mid-term prognosis of patients undergoing coronary artery bypass grafting. PLoS One. 2023 Mar 2;18(3):e0279030. doi: 10.1371/journal.pone.0279030. eCollection 2023.

Reference Type DERIVED
PMID: 36862681 (View on PubMed)

Kwon W, Choi KH, Jeong DS, Lee SY, Lee JM, Park TK, Yang JH, Hahn JY, Choi SH, Chung SR, Cho YH, Sung K, Kim WS, Gwon HC, Lee YT, Song YB. Comparison of long-term cardiovascular and renal outcomes between percutaneous coronary intervention and coronary artery bypass grafting in multi-vessel disease with chronic kidney disease. Front Cardiovasc Med. 2022 Sep 12;9:951113. doi: 10.3389/fcvm.2022.951113. eCollection 2022.

Reference Type DERIVED
PMID: 36172577 (View on PubMed)

Choi KH, Song YB, Jeong DS, Jang YH, Hong D, Lee SY, Youn T, Bak M, Min KM, Lee JM, Park TK, Yang JH, Hahn JY, Choi JH, Choi SH, Chung SR, Cho YH, Sung K, Kim WS, Gwon HC, Lee YT. Differential effects of dual antiplatelet therapy in patients presented with acute coronary syndrome vs. stable ischaemic heart disease after coronary artery bypass grafting. Eur Heart J Cardiovasc Pharmacother. 2021 Nov 3;7(6):517-526. doi: 10.1093/ehjcvp/pvaa080.

Reference Type DERIVED
PMID: 33075126 (View on PubMed)

Other Identifiers

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CABG2019

Identifier Type: -

Identifier Source: org_study_id

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