Protocol to Validate the Performance of the Mellitus Glycated CD59 ELISA for Gestational Diabetes Screening

NCT ID: NCT03865901

Last Updated: 2019-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-31

Study Completion Date

2020-09-30

Brief Summary

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Demonstrate effective performance of the Mellitus GCD59 Test (an ELISA) in screening for gestational diabetes mellitus (GDM)

Detailed Description

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Validate the performance of the Mellitus GCD59 ELISA as a screening test for GDM by evaluating its negative predictive value (NPV) and positive predictive value (PPV) to identify pregnant women at risk for GDM. Sensitivity and specificity of the Mellitus GCD59 ELISA will also be evaluated.

Conditions

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Gestational Diabetes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Non-diabetic pregnant women

Non-diabetic women with singleton pregnancy undergoing screening for gestational diabetes who provide plasma samples for testing with the Mellitus GCD59 Test

Mellitus GCD59 Test

Intervention Type DIAGNOSTIC_TEST

An ELISA for screening for the risk of gestational diabetes

Interventions

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Mellitus GCD59 Test

An ELISA for screening for the risk of gestational diabetes

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Mellitus GCD59 ELISA

Eligibility Criteria

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Inclusion Criteria

1. Women 18 years of age or older at enrollment
2. Has an established viable singleton pregnancy
3. Is recommended for routine GDM screening between 24-28 weeks gestation
4. Has confirmed gestational age of 24-28 weeks at the Screening Visit
5. Is willing and able to provide documentation of informed consent

Exclusion Criteria

1. Has diabetes before pregnancy or has already been diagnosed with GDM
2. Has contraindications for drinking oral glucose solution up to 100 g of sugar
3. Is taking metformin for any reason
4. Has any concomitant illness, disease or condition that, in the clinical judgment of the investigator, is likely to prevent the subject from complying with any aspect of the protocol, or that may put the subject at unacceptable risk
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Regulatory and Clinical Research Institute Inc

OTHER

Sponsor Role collaborator

Mellitus, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joyce A Lonergan

Role: STUDY_CHAIR

Mellitus, LLC

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status

UC Irvine Health

Orange, California, United States

Site Status

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Site Status

Christina Care Health System

Newark, Delaware, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

Boston Medical Center

Boston, Massachusetts, United States

Site Status

UMass Medical School/UMass Memorial Health Care

Worcester, Massachusetts, United States

Site Status

Spectrum Hleath

Grand Rapids, Michigan, United States

Site Status

University of North Carolina, Chapel Hill

Chapel Hill, North Carolina, United States

Site Status

MetroHealth Medical Center

Cleveland, Ohio, United States

Site Status

Ohio State University School of Medicine

Columbus, Ohio, United States

Site Status

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Greenville Health System

Greenville, South Carolina, United States

Site Status

Austin Maternal-Fetal Medicine

Austin, Texas, United States

Site Status

University of Texas Medical Branch

Galveston, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

University of Texas Health Science Center, San Antonio

San Antonio, Texas, United States

Site Status

University of Utah School of Medicine

Salt Lake City, Utah, United States

Site Status

Eastern Virginia Medical School

Norfolk, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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CSP-MEL-002

Identifier Type: -

Identifier Source: org_study_id

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