Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy
NCT ID: NCT05846191
Last Updated: 2023-05-06
Study Results
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Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2023-12-05
2025-03-10
Brief Summary
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2. To study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes.
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Detailed Description
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GDM can increase the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases in pregnant women, and the risk of metabolic disorders in their offspring is high, so it's called a disease that affects two generations.(1) The relationship between maternal hyperglycemia and fetal macrosomia together with other complications has been confirmed.(2) Women with GDM have a higher long-term risk of type 2 diabetes mellitus.(3) Pentraxin 3 (PTX3) and high sensitive CRP are both the acute phase proteins belonging to the pentraxin family but with different biological characteristics, CRP belongs to the short PTX, which is an acute phase protein synthesized by the hepatocytes when the body is stimulated by microbial invasion or tissue damage.(4) PTX3 is a long-chain PTX protein. A variety of tissue cells can produce PTX3 under the stimulation of pro-inflammatory factors, including the endothelial cells, fibroblasts, monocytes, adipocytes, etc.(5,6) There is one study(Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus , 2019) , that has come to PTX3 and hs-CRP may be related to the pathogenesis of GDM, and they are significantly increased in the second trimester, which provides a new idea for early prevention and treatment of GDM .
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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serum pentraxin 3 and high sensitive CRP
female with gestational diabetes mellitus in 2nd trimester
serum pentraxin 3 and high sensitive CRP
serum pentraxin 3 and high sensitive CRP
Interventions
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serum pentraxin 3 and high sensitive CRP
serum pentraxin 3 and high sensitive CRP
Eligibility Criteria
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Inclusion Criteria
2. Diagnosed GDM. 3Gestational age \>20weeks
Exclusion Criteria
2. Women with chronic diseases.
3. Twin pregnancy.
FEMALE
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Mai Mohammed Hosny
Resident doctor
Central Contacts
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References
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Zhao B, Han X, Meng Q, Luo Q. Early second trimester maternal serum markers in the prediction of gestational diabetes mellitus. J Diabetes Investig. 2018 Jul;9(4):967-974. doi: 10.1111/jdi.12798. Epub 2018 Jan 28.
Dongel I, Gokmen AA, Gonen I, Kaya S. Pentraxin-3 and inflammatory biomarkers related to posterolateral thoracotomy in Thoracic Surgery. Pak J Med Sci. 2019 Mar-Apr;35(2):464-469. doi: 10.12669/pjms.35.2.181.
Other Identifiers
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Evaluation of S.pentraxin3&CRP
Identifier Type: -
Identifier Source: org_study_id
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