Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-01

Study Completion Date

2030-08-30

Brief Summary

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The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.

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Detailed Description

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Conditions

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Cognitive Decline Cognitive Change Cognitive Impairment Postoperative Delirium Anesthesia; Reaction Anesthesia; Adverse Effect

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Neurocognitive Assessment Arm

Neurocognition Interventions

Intervention Type COMBINATION_PRODUCT

EEG, Neurocognitive Battery Testing, and Immune Profiles

Interventions

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Neurocognition Interventions

EEG, Neurocognitive Battery Testing, and Immune Profiles

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* At least 65 years old (inclusive)
* Non cardiac general elective surgery
* General anesthesia is expected for 2+ hours

Exclusion Criteria

* Alzheimer's
* Dementia
* Parkinson's
* History of neurodegenerative diseases
* Medication for depression (ie. Benzodiazepines)
* Alcoholism
* Discretion of PI

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No