Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
NCT ID: NCT03839069
Last Updated: 2019-02-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2016-09-30
2021-06-30
Brief Summary
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Detailed Description
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This study aims to prospectively evaluate the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis. The investigators evaluate the saliva-tear productivity (functional outcome) and the survival of graft (anatomical outcome) every three months. The investigators would also validate whether minor salivary gland transplantation is beneficial for the participant prior to further ocular reconstruction as limbal transplantation and corneal grafting.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Minor Salivary Gland Transplantation
Cicatrizing conjunctivitis patients that received minor salivary gland transplantation for dry eye treatment.
minor salivary gland transplantation
The investigators will harvest the autologous labial salivary gland tissue and transplant to the upper and lower conjunctival fornix of the lesion eye.
Interventions
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minor salivary gland transplantation
The investigators will harvest the autologous labial salivary gland tissue and transplant to the upper and lower conjunctival fornix of the lesion eye.
Eligibility Criteria
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Inclusion Criteria
* unilateral or bilateral cicatrizing conjunctivitis
* severe aqueous deficiency dry eye ( Schirmer I test result of less than 2mm)
* chronic ocular surface disease score (COCS) over 3 points
* Oxford scheme over grade III
Exclusion Criteria
* active corneal melting
* severe xerostomia (modified Schirmer I test result of less than 25mm)
20 Years
85 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Hsiao-Sang Chu, MD, MS
Role: PRINCIPAL_INVESTIGATOR
Department of Ophthalmology, NTUH
Locations
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Department of Ophthalmology, National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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201503027DINB
Identifier Type: -
Identifier Source: org_study_id
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