Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces

NCT ID: NCT03838458

Last Updated: 2020-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-07

Study Completion Date

2020-03-10

Brief Summary

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The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.

Detailed Description

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Conditions

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Hypospadias

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Study

Children with isolated hypospadias

No interventions assigned to this group

Control

Children with planned circumcision

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* To apply for circumcision, not to have any genitourinary abnormalities/conditions for control group.
* To have isolated hypospadias for study group.

Exclusion Criteria

* To have genitourinary surgery before.
Maximum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Trakya University

OTHER

Sponsor Role lead

Responsible Party

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Irem Inanc

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dincer Avlan, Profesor, MD

Role: PRINCIPAL_INVESTIGATOR

Trakya University Faculty of Medicine, Pediatric Surgery Department

Locations

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Trakya University Faculty of Medicine

Edirne, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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Hypospadic prepuce structure

Identifier Type: -

Identifier Source: org_study_id

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