NuShield in Surgical Peroneal Tendon Repair

NCT ID: NCT03828916

Last Updated: 2020-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-30

Study Completion Date

2021-06-30

Brief Summary

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The purpose of this study is to evaluate the use of NuShield in subjects requiring surgical tendon repair.

Detailed Description

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The objective of this clinical trial is to evaluate both the safety and efficacy of using the NuShield® allograft in addition to standard of care surgical procedures in subjects requiring surgical repair of the peroneal tendon. The effects of this treatment will be assessed using:

* Questionnaires

* Visual Analog Scale Foot and Ankle (VAS FA)
* FAAM Sport
* PROMIS Global Health SF
* Tegner Activity Scale
* Foot and Ankle Outcomes Instrument (Q1, Q2)
* Swelling assessments
* Ultrasound imaging for tendon thickness, gliding and adhesion formation

Conditions

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Tendon Injuries Tendinopathy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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NuShield

Group Type OTHER

NuShield

Intervention Type OTHER

SOC surgery with the addition of NuShield

Interventions

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NuShield

SOC surgery with the addition of NuShield

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Ages 18 to 60 inclusive
* If female, actively practicing a medically relevant method of contraception, abstinent, surgically sterile, or post-menopausal (defined as no menses for at least 12 months)
* Have a diagnosis of one of the following in relation to the peroneal tendon:

* Tendonitis with MRI confirmation
* Synovial inflammation
* Tear
* Diagnosis resulting from acute injury to the tendon

Exclusion Criteria

* BMI equal to or greater than 35
* Prior injury to the peroneal tendon
* Collagen disorders
* Inflammatory arteriopathies
* Immune compromised
* Diabetic
* Less than 6 months between injury and proposed surgery date
* Steroid injection within the past 6 weeks localized to the treatment area
* Pregnant within the past six (6) months, breast feeding and/or desire to become pregnant during the course of the study, as verified by urine pregnancy test within one week prior to treatment
* History of more than two (2) weeks treatment with immuno-suppressants, including systemic corticosteroids or cytotoxic chemotherapy within one month prior to initial screening, or have received such medications during the screening period, or are anticipated to require such medications during the course of the study
* Taking any investigational drug(s) or therapeutic device(s) within 30 days preceding screening
* History of radiation therapy of the affected foot
* Known history of having Acquired Immunodeficiency Syndrome (AIDS) or HIV
* Currently involved in medical litigation, including Worker's Compensation claims of any type
* Unable to understand the objectives of the trial
* Presence of any condition(s) which, in the opinion of the investigator, would compromise the subject's ability to complete this study
* Having a known history of poor adherence with medical treatment
* Express an unwillingness to receive human allograft tissue
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Organogenesis

INDUSTRY

Sponsor Role collaborator

NuTech Medical, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Central Research Associates, Inc.

Birmingham, Alabama, United States

Site Status RECRUITING

University of Colorado Health Orthopedics Clinic - Anschutz Medical Campus

Aurora, Colorado, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Katie Mowry

Role: CONTACT

205-800-8301

Facility Contacts

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Shannon Helton, RN

Role: primary

205-327-1077

Role: primary

720-848-1900

Other Identifiers

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RD2018-01-01

Identifier Type: -

Identifier Source: org_study_id

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