Adaprev in Digital Flexor Tendon Repair

NCT ID: NCT01014494

Last Updated: 2010-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-12-31

Brief Summary

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This study is being undertaken to verify the safety and performance of Adaprev™, a Class III medical device, when administered as a short term implant into the tendon sheath at the time of surgery, on the post-operative function of severed digital tendons. Subjects are randomised to either Adaprev or standard care and attend visits for 26 weeks following surgery. This clinical investigation will recruit 44 subjects in the UK at up to 10 clinical trial sites.

Detailed Description

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Conditions

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Tendon Injuries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Active - Adaprev

Adaprev (Class III medical device)

Group Type EXPERIMENTAL

Adaprev

Intervention Type DEVICE

Class III Medical Device

Standard Care

No different treatment to normal

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Adaprev

Class III Medical Device

Intervention Type DEVICE

Other Intervention Names

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Product contains mannose-6-phosphate

Eligibility Criteria

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Inclusion Criteria

\- Subjects aged 18 years and above with complete division of the Flexor Digitorum Profundus (FDP) tendon in Zone II.

Exclusion Criteria

* Subjects with additional complicated injuries
* Subjects whose flexor tendon repair involves a finger with less than full tendon function prior to the injury requiring repair
* Subjects who are undergoing surgical repair of the severed tendon(s) more than four days after the injury occurred.
* Subjects with a history of clinical significant hypersensitivity to any of the devices, drugs or surgical dressings to be used in this trial.
* Subjects with conditions which may delay healing.
* Subjects who are taking, or have taken, any investigational drugs within 3 months prior to the screening visit.
* Females who are pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Renovo

INDUSTRY

Sponsor Role lead

Responsible Party

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Renovo

Principal Investigators

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John Hutchison, MBBS PhD

Role: STUDY_DIRECTOR

Renovo Ltd

Locations

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Mr P Gillespie

Addenbrooke's Hospital, Cambridge, Cambridge, United Kingdom

Site Status RECRUITING

University Hospital of South Manchester NHS Foundation Trust

Manchester, Greater Manchester, United Kingdom

Site Status RECRUITING

Mr F Schreuder

The Lister Hospital, Stevenage, Hertfordshire, United Kingdom

Site Status RECRUITING

Royal London Hospital, Barts and The London Hospital

London, London, United Kingdom

Site Status RECRUITING

Royal Free Hospital

London, London, United Kingdom

Site Status RECRUITING

Chelsea & Westminster Hospital

London, London, United Kingdom

Site Status RECRUITING

Mr R Dunn

Salisbury District Hospital, Salisbury, United Kingdom

Site Status RECRUITING

Mr D Warwick

Southampton General Hospital, Southampton, United Kingdom

Site Status RECRUITING

Abertawe Bro Morgannwg University Nhs Trust

Swansea, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Facility Contacts

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Patrick Gillespie

Role: primary

Miss V C Lees

Role: primary

Mr Schreuder

Role: primary

Kamal El-Ali

Role: primary

Donald Dewar

Role: primary

Mr Chakrabarty

Role: primary

Beryl De Souza

Role: backup

Roderick Dunn

Role: primary

David Warwick

Role: primary

Elaine Hayward

Role: backup

Mr D Boyce

Role: primary

Other Identifiers

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RN1008-0083

Identifier Type: -

Identifier Source: org_study_id