Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery
NCT ID: NCT03817359
Last Updated: 2019-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
84 participants
INTERVENTIONAL
2018-08-03
2018-12-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Mix infusion using single TCI pump
participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump infusion
Remifentanil-propofol mixture
Participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump in intervention group. All TCI target concentration adjustments or extra bolus of propofol or remifentanil during operation were based on BIS and ANI monitor.
Separate infusion using two TCI pumps
participants receive total intravenous anesthesia with remifentanil and propofol separately by two TCI pumps infusion
No interventions assigned to this group
Interventions
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Remifentanil-propofol mixture
Participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump in intervention group. All TCI target concentration adjustments or extra bolus of propofol or remifentanil during operation were based on BIS and ANI monitor.
Eligibility Criteria
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Inclusion Criteria
* age more than 18 years
* scheduled for breast cancer surgery under general anesthesia.
Exclusion Criteria
* combining other surgical procedure leading to extended operative time
18 Years
ALL
No
Sponsors
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Tri-Service General Hospital
OTHER
Responsible Party
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Meng-Fu Lai
Resident physician
Principal Investigators
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Zhi-Fu Wu, M.D.
Role: PRINCIPAL_INVESTIGATOR
Department of Anesthesiology, Tri-Service General Hospital
Locations
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Tri-Service General hospital
Taipei, , Taiwan
Countries
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References
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Bedocs P, Evers DL, Buckenmaier CC 3rd. Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil. Anesth Analg. 2019 Jul;129(1):e13-e15. doi: 10.1213/ANE.0000000000003772.
Berkenbosch JW, Graff GR, Stark JM, Ner Z, Tobias JD. Use of a remifentanil-propofol mixture for pediatric flexible fiberoptic bronchoscopy sedation. Paediatr Anaesth. 2004 Nov;14(11):941-6. doi: 10.1111/j.1460-9592.2004.01355.x.
Stewart JT, Warren FW, Maddox FC, Viswanathan K, Fox JL. The stability of remifentanil hydrochloride and propofol mixtures in polypropylene syringes and polyvinylchloride bags at 22 degrees-24 degrees C. Anesth Analg. 2000 Jun;90(6):1450-1. doi: 10.1097/00000539-200006000-00037.
Other Identifiers
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2-107-05-079
Identifier Type: -
Identifier Source: org_study_id
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