Rota China Registry

NCT ID: NCT03806621

Last Updated: 2023-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

980 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-18

Study Completion Date

2022-01-20

Brief Summary

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Rotational atherectomy (RA) facilitates percutaneous coronary intervention for complex de novo lesions with severe calcification. Some observational studies and a small randomized trial indicated that a strategy of routine RA did not conferred reduction in restenosis or MACE, but these studies are limited by missing follow-up, insufficient power to compare outcomes, and confounding factors in the RA group (long lesion length, etc.). With recent developments in medical therapy, advances in design and delivery of drug-eluting stents (DES), and advances in noninvasive and intravascular coronary imaging, the use of RA in current real-world practice remains to be well determined. We aimed to compile real-world clinical outcomes data for the RotablatorTM Rotational Atherectomy System in routine clinical practice in China.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Rotational Atherectomy

Rotational Atherectomy

Intervention Type PROCEDURE

Patients with severe calcified lesions will receive rotational atherectomy during index PCI

Interventions

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Rotational Atherectomy

Patients with severe calcified lesions will receive rotational atherectomy during index PCI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years old
* Subject who is clinically indicated for PCI/stenting
* Written informed consent
* Subject is willing to comply with all protocol-required follow-up evaluation

* Target lesion is moderately to severely calcified by visual estimate
* Unsuccessful balloon dilatation of the target lesion
* Unsuccessful passage of device(s) (microcatheter, balloon, or stent) across the target lesion

Exclusion Criteria

* Subject has clinical symptoms and/or electrocardiogram (ECG) changes consistent with acute MI within 2 weeks
* Subject has any of the following angiographic findings:

* Thrombus present in the target vessel (by visual estimate)
* Significant dissection present in the target vessel (NHLBI types C-F)
* Lesion angulation \> 60°(by visual estimate)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BSC International Medical Trading (Shanghai) Co., Ltd.

OTHER

Sponsor Role collaborator

Beijing Anzhen Hospital

OTHER

Sponsor Role lead

Responsible Party

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Shao-Ping Nie

Professor of Medicine, Director, Center for Coronary Artery Disease, Division of Cardiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The First Affiliated Hospital of USTC

Hefei, Anhui, China

Site Status

Beijing Anzhen Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Beijing Hospital

Beijing, Beijing Municipality, China

Site Status

Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, China

Site Status

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science

Guangzhou, Guangdong, China

Site Status

The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status

Fuwai Central China Cardiovascular Hospital

Zhengzhou, Henan, China

Site Status

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Site Status

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Site Status

Nanjing First hospital, Nanjing Medical University

Nanjing, Jiangsu, China

Site Status

First Hospital of China Medical University

Shenyang, Liaoning, China

Site Status

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

Site Status

Xijing Hospital, the Fourth Military Medical University

Xi'an, Shaanxi, China

Site Status

Qilu Hospital (Qingdao), Shandong University

Jinan, Shandong, China

Site Status

West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status

Tianjin Fourth Central Hospital

Tianjin, Tianjin Municipality, China

Site Status

The First People's Hospital of Yunnan Province

Kunming, Yunnan, China

Site Status

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

Countries

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China

References

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Wang X, Zhang H, Bai X, Zhang L, Li C, Mao X, Chen J, Luo J, Zhao Y, Zhou B, You B, Zhang Y, Ma L, Du Z, Chen Y, Sun F, Qiu C, Shen Z, Wen S, Mintz GS, Ye F, Nie S; China Rota Elite Group. Practices and outcomes of rotational atherectomy in China: The Rota China registry. Catheter Cardiovasc Interv. 2024 Oct;104(4):664-675. doi: 10.1002/ccd.31211. Epub 2024 Sep 3.

Reference Type DERIVED
PMID: 39223992 (View on PubMed)

Other Identifiers

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2017033

Identifier Type: -

Identifier Source: org_study_id

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