Does a Diet With the Recommended Amount of Polyunsaturated Fatty Acids, Increase Their Proportion in Maternal Milk?

NCT ID: NCT03805997

Last Updated: 2024-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-08

Study Completion Date

2022-04-22

Brief Summary

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During pregnancy and lactation, the consumption of PUFA n-3, through the consumption of food products that contain more ALA than conventional products, could impact nutritional and non-nutritional breast milk quality (immune criteria, metabolites, hormones), and also the implantation of the intestinal microbiota of the newborn, which is involved in preservation of short term and long term health of the child.

Detailed Description

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Conditions

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Breast Feeding

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Experimental Group

consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day

Group Type EXPERIMENTAL

Dietary advice

Intervention Type DEVICE

participants will benefit of dietary device 30-minute dietary advice carried out by a doctor at the University Hospital of Rennes, in order to provide nutritional advice adapted to pregnant women.

Consumption of Bleu-Blanc-Coeur products

Intervention Type OTHER

consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day

Blood sample

Intervention Type BIOLOGICAL

the fatty acid profile of the women red blood cells of the woman wil be test at the inclusion and at 21 days post-partum

Contact

Intervention Type OTHER

Participants of the group A will be contacted by phone,sms, mail by a technician every 15 days from 7th month of pregnancy to the 8th month of pregnancy and then every week from the 9th month of pregnancy to the 45th postpartum day (except the week of childbirth), in order to collect their consumption data of the delivered food products.

food questionnaire

Intervention Type OTHER

Participants will have to complete a food questionnaire at the inclusion and at 21 days post-partum

newborn faeces sample

Intervention Type OTHER

Newborn faeces sample will be collected at 21 Days post partum

breast milk sample

Intervention Type OTHER

Breast milk sample will be collected at 21 days and 45 days post partum

Control Group

no consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day. This group will receive Système U vouchers.

Group Type PLACEBO_COMPARATOR

Dietary advice

Intervention Type DEVICE

participants will benefit of dietary device 30-minute dietary advice carried out by a doctor at the University Hospital of Rennes, in order to provide nutritional advice adapted to pregnant women.

No consumption of Bleu-Blanc-Coeur products

Intervention Type OTHER

no consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day. This group will receive Système U vouchers.

Blood sample

Intervention Type BIOLOGICAL

the fatty acid profile of the women red blood cells of the woman wil be test at the inclusion and at 21 days post-partum

food questionnaire

Intervention Type OTHER

Participants will have to complete a food questionnaire at the inclusion and at 21 days post-partum

newborn faeces sample

Intervention Type OTHER

Newborn faeces sample will be collected at 21 Days post partum

breast milk sample

Intervention Type OTHER

Breast milk sample will be collected at 21 days and 45 days post partum

Interventions

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Dietary advice

participants will benefit of dietary device 30-minute dietary advice carried out by a doctor at the University Hospital of Rennes, in order to provide nutritional advice adapted to pregnant women.

Intervention Type DEVICE

Consumption of Bleu-Blanc-Coeur products

consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day

Intervention Type OTHER

No consumption of Bleu-Blanc-Coeur products

no consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day. This group will receive Système U vouchers.

Intervention Type OTHER

Blood sample

the fatty acid profile of the women red blood cells of the woman wil be test at the inclusion and at 21 days post-partum

Intervention Type BIOLOGICAL

Contact

Participants of the group A will be contacted by phone,sms, mail by a technician every 15 days from 7th month of pregnancy to the 8th month of pregnancy and then every week from the 9th month of pregnancy to the 45th postpartum day (except the week of childbirth), in order to collect their consumption data of the delivered food products.

Intervention Type OTHER

food questionnaire

Participants will have to complete a food questionnaire at the inclusion and at 21 days post-partum

Intervention Type OTHER

newborn faeces sample

Newborn faeces sample will be collected at 21 Days post partum

Intervention Type OTHER

breast milk sample

Breast milk sample will be collected at 21 days and 45 days post partum

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* women over 18;
* ≤ 28th week of amenorrhea
* having a project of exclusive breastfeeding until at least the 45th day postpartum;
* BMI before pregnancy between 18.5 and 30.0;
* consuming frequently dairy products, eggs, meat (pork, beef, poultry);
* accepting the consumption of all food products delivered;
* written consent received and signed.


* multiple pregnancy;
* eating disorders or suspicion (defined by SCOFF score);
* vegetarian, vegan or flexitarian;
* allergic to food product(s) involved in the study;
* home with more than 2 adults and 3 children (excluding foetus);
* adults on legal protection (guardianship, trusteeship…), persons deprived of liberty;

Exclusion Criteria

* Interruption of breastfeeding before the 21st postpartum day
* Prematurity: childbirth before the 37th week of amenorrhea
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Rennes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CIC CHU de Rennes

Rennes, , France

Site Status

Countries

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France

Other Identifiers

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35RC17_8820

Identifier Type: -

Identifier Source: org_study_id

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