Study on Short Chain Fatty Acids Concentration in Breast Milk and Its Correlation With the Maternal Diet
NCT ID: NCT02301728
Last Updated: 2014-11-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2014-12-31
2015-05-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Interventions
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sampling of breast milk, obtaining information about the maternal diet
take samples of 3 ml breast milk and 3-days diet diaries
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* diabetes and other chronic diseases at the level of each organ or system,
* diseases of pregnancy.
* antibiotics, prebiotics, probiotics and synbiotics in the 30 days prior to the first observation.
FEMALE
Yes
Sponsors
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Federico II University
OTHER
Responsible Party
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Annalisa Passariello
MD, PhD
Principal Investigators
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Annalisa Passariello, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
"Federico II" University of Naples
Locations
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"Federico II" University of Naples
Naples, Naples, Italy
Countries
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Central Contacts
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Facility Contacts
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Annalisa Passariello, MD, PhD
Role: primary
roberto berni canani, MD, PhD
Role: backup
References
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Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001 Jul;81(3):1031-64. doi: 10.1152/physrev.2001.81.3.1031.
Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003 Feb;62(1):67-72. doi: 10.1079/PNS2002207.
Resta-Lenert S, Truong F, Barrett KE, Eckmann L. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1837-49. doi: 10.1152/ajpcell.2001.281.6.C1837.
Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980 Sep;21(9):793-8. doi: 10.1136/gut.21.9.793.
Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev. 2002 Jan;82(1):245-89. doi: 10.1152/physrev.00026.2001.
Binder HJ, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. 1989 Apr;96(4):989-96. doi: 10.1016/0016-5085(89)91614-4.
Boffa LC, Gruss RJ, Allfrey VG. Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions. J Biol Chem. 1981 Sep 25;256(18):9612-21.
Belderbos ME, Houben ML, van Bleek GM, Schuijff L, van Uden NO, Bloemen-Carlier EM, Kimpen JL, Eijkemans MJ, Rovers M, Bont LJ. Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. Pediatr Allergy Immunol. 2012 Feb;23(1):65-74. doi: 10.1111/j.1399-3038.2011.01230.x. Epub 2011 Nov 22.
Other Identifiers
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BMB-100
Identifier Type: -
Identifier Source: org_study_id