Exercise and Overnight Motor Sequence Task

NCT ID: NCT03800368

Last Updated: 2019-01-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 51 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-12-21
• Study Completion Date: 2017-09-01

Brief Summary

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Conditions

Schizophrenia and Related Disorders; Psychotic Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

High-endurance group

This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state.

Group Type: EXPERIMENTAL

Exercise

Intervention Type: OTHER

Indoor cycling exercise intervention

Low-endurance group

This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level.

Group Type: EXPERIMENTAL

Exercise

Intervention Type: OTHER

Indoor cycling exercise intervention

Psycho-education

This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc).

Group Type: ACTIVE_COMPARATOR

Non-exercise

Intervention Type: OTHER

Psycho-education

Interventions

Exercise

Indoor cycling exercise intervention

Intervention Type: OTHER

Non-exercise

Psycho-education

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Aged from 18 to 55
• Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
• Ability to understand the nature of the study and to give written informed consent

Exclusion Criteria

• Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
• Comorbid substance dependence
• Unstable psychotic symptoms
• A history of brain trauma or organic brain disease
• Known history of intellectual disability or special school attendance
• Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The University of Hong Kong

OTHER

Sponsor Role: lead

Responsible Party

Dr. Lincoln Lik-Hang Lo

Postdoctoral Fellow

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Lik Hang Lincoln Lo

Role: PRINCIPAL_INVESTIGATOR

The University of Hong Kong

References

Lo LLH, Lee EHM, Hui CLM, Chong CSY, Chang WC, Chan SKW, Lin JJ, Lo WTL, Chen EYH. Effect of high-endurance exercise intervention on sleep-dependent procedural memory consolidation in individuals with schizophrenia: a randomized controlled trial. Psychol Med. 2023 Apr;53(5):1708-1720. doi: 10.1017/S0033291721003196. Epub 2021 Oct 7.

Reference Type: DERIVED

PMID: 34615565 (View on PubMed)

Other Identifiers

HKU_Psych

Identifier Type: -

Identifier Source: org_study_id