Percutaneous Device Closure for Significant Paravalvular Leakage After Transcatheter or Surgical Valve Replacement

NCT ID: NCT03793296

Last Updated: 2019-02-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-31

Study Completion Date

2026-12-31

Brief Summary

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This study evaluates the effectiveness and safety of Percutaneous Device Closure for Significant Paravalvular Leakage after transcatheter or surgical valve replacement.

Detailed Description

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Conditions

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Cardiac Valves Heart Valve Diseases Valvular Insufficiency

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Paravalvular leak

After transcatheter- or surgical valve replacement

Group Type EXPERIMENTAL

Percutaneous Device Closure: Vascular plug

Intervention Type DEVICE

percutaneous transcatheter approach into cardiac valve

Interventions

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Percutaneous Device Closure: Vascular plug

percutaneous transcatheter approach into cardiac valve

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Significant Paravalvular Leakage After Transcatheter or Surgical Valve Replacement
* Required treatment of paravalvular leakage due to heart failure or hemolysis
* There is a formal agreement of heart team as following

* predicted high-risk (STS score ≥8 OR Logistic EuroSCORE ≥20% OR operative mortality is ≥15%)
* Inoperable status due to old age or frailty
* Written consent

Exclusion Criteria

* Risk of valve embolization because of valve dehiscence or instability
* Acute myocardial ischemia (enzyme elevation, ST elevation on EKG(electrocardiogram), or chest pain/discomfort)
* Evidence of intracardiac mass, thrombus or vegetation on Transthoracic/Transesophageal echocardiographic study
* Life expectancy less than 6 months due to non-cardiac disease
* Pregnant or breastfeeding
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CardioVascular Research Foundation, Korea

OTHER

Sponsor Role collaborator

Seung-Jung Park

OTHER

Sponsor Role lead

Responsible Party

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Seung-Jung Park

Professor, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Asan Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AMCCV2018-11

Identifier Type: -

Identifier Source: org_study_id

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