Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
80 participants
INTERVENTIONAL
2018-05-01
2023-01-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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Placebo
Placebo
Lysergic Acid Diethylamide
Drug will be administered in solution form.
low dose MDMA
6.5ug dose of serotonin agonist
Lysergic Acid Diethylamide
Drug will be administered in solution form.
medium dose
13ug dose of serotonin agonist
Lysergic Acid Diethylamide
Drug will be administered in solution form.
high dose
26ug dose of serotonin agonist
Lysergic Acid Diethylamide
Drug will be administered in solution form.
Interventions
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Lysergic Acid Diethylamide
Drug will be administered in solution form.
Eligibility Criteria
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Inclusion Criteria
* High school level education
* BMI between 19 and 30
Exclusion Criteria
* women who are nursing, pregnant, or plan to become pregnant within 3 months
* History of psychotic disorder or family history of psychotic disorder
18 Years
35 Years
ALL
Yes
Sponsors
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University of Chicago
OTHER
Responsible Party
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Locations
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Matthew Bona
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Countries
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References
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Bershad AK, Preller KH, Lee R, Keedy S, Wren-Jarvis J, Bremmer MP, de Wit H. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr;5(4):461-467. doi: 10.1016/j.bpsc.2019.12.007. Epub 2019 Dec 20.
Bershad AK, Schepers ST, Bremmer MP, Lee R, de Wit H. Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers. Biol Psychiatry. 2019 Nov 15;86(10):792-800. doi: 10.1016/j.biopsych.2019.05.019. Epub 2019 Jun 3.
Other Identifiers
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15-1311
Identifier Type: -
Identifier Source: org_study_id
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