Serotonin and Motor Plasticity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-01

Study Completion Date

2017-11-30

Brief Summary

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With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy humans.

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Detailed Description

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Microdialysis findings in animal models provide evidence for a monoaminergic augmentation of motor function. However, this evidence is largely limited to noradrenaline and dopamine, with little evidence to support a similar effect for serotonin. What remains to be tested therefore, is whether acute serotonergic administration induces neural or behavioral changes during motor learning also. Using a sample of 60 female participants (with the possible inclusion of male participants at a later date), the investigators aim to test the effects of a serotonergic challenge on motor learning and plasticity in healthy participants.

Conditions

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Healthy Controls

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Double-blind

Study Groups

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Interventional group

Half of the participants (n = 30) will receive 20mg of the SSRI Escitalopram.

Group Type EXPERIMENTAL

Escitalopram

Intervention Type DRUG

Experimental group participants (n = 30) will receive 20 mg of Escitalopram for 7 days.

Control group

Half of the participants ( n= 30) will receive the placebo.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Control group participants (n = 30) will receive a placebo for 7 days.

Interventions

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Escitalopram

Experimental group participants (n = 30) will receive 20 mg of Escitalopram for 7 days.

Intervention Type DRUG

Placebo

Control group participants (n = 30) will receive a placebo for 7 days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* female
* right-handed
* healthy
* has taken oral contraceptives (ovulation inhibitor) continuously for at least 3 months
* has read and agreed to study parameters

Exclusion Criteria

* tattoos on head or neck
* non-removable metal on or in body
* alcohol abuse
* is currently taking medication
* smokes more than 3 cigarettes per day
* positive drug test
* pregnancy
* plays an instrument professionally
* plays videogames more than 2 hours per week
* is a professional athlete
* suffers from migraines
* has taken part in another study, where motor learning skills and/or medication is a factor, in the last 3 months
* heart rhythm disorders (long QT)
* hypertension
* calcium or magnesium deficiency
* neurological disorders
* chronic metabolic disorders
* liver or kidney diseases
* immunodeficiency
* endocrine disorders
* psychiatric disorders
* tumors
* injuries to the head and brain

Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes