Study Results
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Basic Information
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COMPLETED
NA
54 participants
INTERVENTIONAL
2019-03-01
2023-02-28
Brief Summary
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Hypothesis to be tested. Our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia.
Design and subjects. A total of 36 patients with amblyopia will be randomized allocated into two intervention groups: Group 1, perceptual learning therapy. Group 2, occlusion therapy. A control group comprising of 18 subjects with normal vision will be recruited for comparison. A battery of tests will be used to assess a range of visual functions before and after the treatment intervention.
Study instruments. Grating acuity testing system
Interventions. We have established a clinical protocol for acuity training. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to indicate the location of the stimulus. Participants will be required to undertake 20 one-hour sessions of training.
Main outcome measures. Resolution acuity, visual acuity, contrast sensitivity function
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Perceptual learning group - Amblyopia
Visual training
Acuity training
The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.
Perceptual learning group - Control
Visual training
Acuity training
The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.
Occlusion therapy - Amblyopia
Patching
Occlusion therapy
Participants will be required to patch the good eye for 20 days, 1 hour per day.
Interventions
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Acuity training
The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.
Occlusion therapy
Participants will be required to patch the good eye for 20 days, 1 hour per day.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
7 Years
ALL
Yes
Sponsors
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The Hong Kong Polytechnic University
OTHER
Responsible Party
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Principal Investigators
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Tsz Wing Leung, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
The Hong Kong Polytechnic University
Locations
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Optometry Research Clinic
Hong Kong, , Hong Kong
Countries
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References
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Levi DM, Li RW. Improving the performance of the amblyopic visual system. Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):399-407. doi: 10.1098/rstb.2008.0203.
Li RW, Klein SA, Levi DM. Prolonged perceptual learning of positional acuity in adult amblyopia: perceptual template retuning dynamics. J Neurosci. 2008 Dec 24;28(52):14223-9. doi: 10.1523/JNEUROSCI.4271-08.2008.
Li RW, Ngo C, Nguyen J, Levi DM. Video-game play induces plasticity in the visual system of adults with amblyopia. PLoS Biol. 2011 Aug;9(8):e1001135. doi: 10.1371/journal.pbio.1001135. Epub 2011 Aug 30.
Other Identifiers
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HSEARS20171108002
Identifier Type: -
Identifier Source: org_study_id
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