Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents
NCT ID: NCT03786042
Last Updated: 2025-09-26
Study Results
Results available
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
139 participants
Study Classification
INTERVENTIONAL
Study Start Date
2019-02-04
Study Completion Date
2021-12-09
Brief Summary
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This research aims to investigate how exposure to advertising for Electronic Nicotine Delivery Systems (commonly called e-cigarettes) may lead to combustible smoking initiation in adolescents.
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Detailed Description
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\[3/14/2020\]: Study recruitment temporarily halted due to the COVID-19 pandemic
Conditions
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Attentional Bias
Smoking Cues
Positive Perceptions About Cigarette Smoking
Social Norms
Smoking Susceptibility
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
FACTORIAL
Primary Study Purpose
PREVENTION
Blinding Strategy
SINGLE
Participants
Study Groups
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E-cigarette ad exposure
Participants in the e-cigarette ad exposure condition will view e-cigarette ads on the computer screen while having their eye movements tracked
Group Type
ACTIVE_COMPARATOR
E-cigarette ad exposure
Intervention Type
BEHAVIORAL
Participants view a series of e-cigarette TV commercials
non e-cigarette ad exposure
Participants in the non e-cigarette ad exposure condition will view non e-cigarette ads on the computer screen while having their eye movements tracked
Group Type
SHAM_COMPARATOR
non e-cigarette TV commercials
Intervention Type
OTHER
Participants view a series of non e-cigarette TV commercials
Interventions
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E-cigarette ad exposure
Participants view a series of e-cigarette TV commercials
Intervention Type
BEHAVIORAL
non e-cigarette TV commercials
Participants view a series of non e-cigarette TV commercials
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
\-
Minimum Eligible Age
14 Years
Maximum Eligible Age
17 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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National Cancer Institute (NCI)
NIH
Sponsor Role
collaborator
Dartmouth College
OTHER
Sponsor Role
collaborator
Trustees of Dartmouth College
OTHER
Sponsor Role
lead
Responsible Party
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Diane Gilbert-Diamond
Associate Professor
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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James Sargent, MD
Role: PRINCIPAL_INVESTIGATOR
Geisel School of Medicine at Dartmouth College
Diane Gilbert-Diamond, ScD
Role: PRINCIPAL_INVESTIGATOR
Geisel School of Medicine at Dartmouth College
Locations
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Dartmouth-Hithchock Medical Center
Lebanon, New Hampshire, United States
Site Status
Countries
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United States
References
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Singh T, Agaku IT, Arrazola RA, Marynak KL, Neff LJ, Rolle IT, King BA. Exposure to Advertisements and Electronic Cigarette Use Among US Middle and High School Students. Pediatrics. 2016 May;137(5):e20154155. doi: 10.1542/peds.2015-4155.
Reference Type
BACKGROUND
National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. Preventing Tobacco Use Among Youth and Young Adults: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US); 2012. Available from http://www.ncbi.nlm.nih.gov/books/NBK99237/
Reference Type
BACKGROUND
Pierce JP, Sargent JD, White MM, Borek N, Portnoy DB, Green VR, Kaufman AR, Stanton CA, Bansal-Travers M, Strong DR, Pearson JL, Coleman BN, Leas E, Noble ML, Trinidad DR, Moran MB, Carusi C, Hyland A, Messer K. Receptivity to Tobacco Advertising and Susceptibility to Tobacco Products. Pediatrics. 2017 Jun;139(6):e20163353. doi: 10.1542/peds.2016-3353.
Reference Type
BACKGROUND
Villanti AC, Rath JM, Williams VF, Pearson JL, Richardson A, Abrams DB, Niaura RS, Vallone DM. Impact of Exposure to Electronic Cigarette Advertising on Susceptibility and Trial of Electronic Cigarettes and Cigarettes in US Young Adults: A Randomized Controlled Trial. Nicotine Tob Res. 2016 May;18(5):1331-9. doi: 10.1093/ntr/ntv235. Epub 2015 Nov 16.
Reference Type
BACKGROUND
Heatherton TF, Sargent JD. Does Watching Smoking in Movies Promote Teenage Smoking? Curr Dir Psychol Sci. 2009 Apr 15;18(2):63-67. doi: 10.1111/j.1467-8721.2009.01610.x.
Reference Type
BACKGROUND
Sargent JD, Beach ML, Adachi-Mejia AM, Gibson JJ, Titus-Ernstoff LT, Carusi CP, Swain SD, Heatherton TF, Dalton MA. Exposure to movie smoking: its relation to smoking initiation among US adolescents. Pediatrics. 2005 Nov;116(5):1183-91. doi: 10.1542/peds.2005-0714.
Reference Type
BACKGROUND
Dal Cin S, Gibson B, Zanna MP, Shumate R, Fong GT. Smoking in movies, implicit associations of smoking with the self, and intentions to smoke. Psychol Sci. 2007 Jul;18(7):559-63. doi: 10.1111/j.1467-9280.2007.01939.x.
Reference Type
BACKGROUND
National Cancer Institute. The role of the media in promoting and reducing tobacco use. Tobacco control monograph No. 19. (2008).
Reference Type
BACKGROUND
Centers for Disease Control and Prevention. Smoking in Movies. Available at: https://www.cdc.gov/tobacco/data_statistics/fact_sheets/youth_data/movies/index.htm. (Accessed: 5 November 2016)
Reference Type
BACKGROUND
Duke JC, Lee YO, Kim AE, Watson KA, Arnold KY, Nonnemaker JM, Porter L. Exposure to electronic cigarette television advertisements among youth and young adults. Pediatrics. 2014 Jul;134(1):e29-36. doi: 10.1542/peds.2014-0269. Epub 2014 Jun 2.
Reference Type
BACKGROUND
US Department of Health and Human Services. The health consequences of smoking - 50 years of progress. (2014).
Reference Type
BACKGROUND
King AC, Smith LJ, Fridberg DJ, Matthews AK, McNamara PJ, Cao D. Exposure to electronic nicotine delivery systems (ENDS) visual imagery increases smoking urge and desire. Psychol Addict Behav. 2016 Feb;30(1):106-12. doi: 10.1037/adb0000123. Epub 2015 Nov 30.
Reference Type
BACKGROUND
R, W. & A, S. Handbook of implicit cognition and addiction. (Sage, 2006).
Reference Type
BACKGROUND
Booth P, Albery IP, Frings D. Effect of e-cigarette advertisements and antismoking messages on explicit and implicit attitudes towards tobacco and e-cigarette smoking in 18-65-year-olds: a randomised controlled study protocol. BMJ Open. 2017 Jun 23;7(6):e014361. doi: 10.1136/bmjopen-2016-014361.
Reference Type
BACKGROUND
Baschnagel JS. Using mobile eye-tracking to assess attention to smoking cues in a naturalized environment. Addict Behav. 2013 Dec;38(12):2837-40. doi: 10.1016/j.addbeh.2013.08.005. Epub 2013 Aug 14.
Reference Type
BACKGROUND
Primack BA, Switzer GE, Dalton MA. Improving measurement of normative beliefs involving smoking among adolescents. Arch Pediatr Adolesc Med. 2007 May;161(5):434-9. doi: 10.1001/archpedi.161.5.434.
Reference Type
BACKGROUND
Hanewinkel R, Isensee B, Sargent JD, Morgenstern M. Cigarette advertising and teen smoking initiation. Pediatrics. 2011 Feb;127(2):e271-8. doi: 10.1542/peds.2010-2934. Epub 2011 Jan 17.
Reference Type
BACKGROUND
Stautz K, Brown KG, King SE, Shemilt I, Marteau TM. Immediate effects of alcohol marketing communications and media portrayals on consumption and cognition: a systematic review and meta-analysis of experimental studies. BMC Public Health. 2016 Jun 9;16:465. doi: 10.1186/s12889-016-3116-8.
Reference Type
BACKGROUND
Farrelly MC, Duke JC, Crankshaw EC, Eggers ME, Lee YO, Nonnemaker JM, Kim AE, Porter L. A Randomized Trial of the Effect of E-cigarette TV Advertisements on Intentions to Use E-cigarettes. Am J Prev Med. 2015 Nov;49(5):686-693. doi: 10.1016/j.amepre.2015.05.010. Epub 2015 Jul 7.
Reference Type
BACKGROUND
Soneji S, Pierce JP, Choi K, Portnoy DB, Margolis KA, Stanton CA, Moore RJ, Bansal-Travers M, Carusi C, Hyland A, Sargent J. Engagement With Online Tobacco Marketing and Associations With Tobacco Product Use Among U.S. Youth. J Adolesc Health. 2017 Jul;61(1):61-69. doi: 10.1016/j.jadohealth.2017.01.023. Epub 2017 Mar 28.
Reference Type
BACKGROUND
Lewis-Esquerre JM, Rodrigue JR, Kahler CW. Development and validation of an adolescent smoking consequences questionnaire. Nicotine Tob Res. 2005 Feb;7(1):81-90. doi: 10.1080/14622200412331328475.
Reference Type
BACKGROUND
Grana RA, Ling PM. "Smoking revolution": a content analysis of electronic cigarette retail websites. Am J Prev Med. 2014 Apr;46(4):395-403. doi: 10.1016/j.amepre.2013.12.010.
Reference Type
BACKGROUND
Voigt K. Smoking Norms and the Regulation of E-Cigarettes. Am J Public Health. 2015 Oct;105(10):1967-72. doi: 10.2105/AJPH.2015.302764. Epub 2015 Aug 13.
Reference Type
BACKGROUND
Hunt K, Sweeting H. You have been QUALIFIED for a smokeless e-cig starter kit. J Epidemiol Community Health. 2014 Aug;68(8):786. doi: 10.1136/jech-2014-203879. Epub 2014 Apr 29. No abstract available.
Reference Type
BACKGROUND
Grana R, Benowitz N, Glantz SA. E-cigarettes: a scientific review. Circulation. 2014 May 13;129(19):1972-86. doi: 10.1161/CIRCULATIONAHA.114.007667. No abstract available.
Reference Type
BACKGROUND
Fairchild AL, Bayer R, Colgrove J. The renormalization of smoking? E-cigarettes and the tobacco "endgame". N Engl J Med. 2014 Jan 23;370(4):293-5. doi: 10.1056/NEJMp1313940. Epub 2013 Dec 18. No abstract available.
Reference Type
BACKGROUND
Tyas SL, Pederson LL. Psychosocial factors related to adolescent smoking: a critical review of the literature. Tob Control. 1998 Winter;7(4):409-20. doi: 10.1136/tc.7.4.409.
Reference Type
BACKGROUND
Gerrard, M., Gibbons, F. X., Houlihan, A. E., Stock, M. L. & Pomery, E. A. A dual-process approach to health risk decision making: The prototype willingness model. Dev Rev 28, 29-61 (2008).
Reference Type
BACKGROUND
Frith CD, Frith U. Implicit and explicit processes in social cognition. Neuron. 2008 Nov 6;60(3):503-10. doi: 10.1016/j.neuron.2008.10.032.
Reference Type
BACKGROUND
Wellman RJ, Sugarman DB, DiFranza JR, Winickoff JP. The extent to which tobacco marketing and tobacco use in films contribute to children's use of tobacco: a meta-analysis. Arch Pediatr Adolesc Med. 2006 Dec;160(12):1285-96. doi: 10.1001/archpedi.160.12.1285.
Reference Type
BACKGROUND
Pokhrel P, Fagan P, Herzog TA, Chen Q, Muranaka N, Kehl L, Unger JB. E-cigarette advertising exposure and implicit attitudes among young adult non-smokers. Drug Alcohol Depend. 2016 Jun 1;163:134-40. doi: 10.1016/j.drugalcdep.2016.04.008. Epub 2016 Apr 25.
Reference Type
BACKGROUND
Nosek BA. Moderators of the relationship between implicit and explicit evaluation. J Exp Psychol Gen. 2005 Nov;134(4):565-84. doi: 10.1037/0096-3445.134.4.565.
Reference Type
BACKGROUND
Field, M. & Wiers, R. in Drug Abuse and Addiction in Medical Illness: Causes, Consequences and Treatment (eds. Verster, J. C., Brady, K., Galanter, M. & Conrod, P.) 35-45 (Springer New York, 2012).
Reference Type
BACKGROUND
Hanewinkel R, Sargent JD. Exposure to smoking in internationally distributed American movies and youth smoking in Germany: a cross-cultural cohort study. Pediatrics. 2008 Jan;121(1):e108-17. doi: 10.1542/peds.2007-1201.
Reference Type
BACKGROUND
Sargent JD, Beach ML, Dalton MA, Mott LA, Tickle JJ, Ahrens MB, Heatherton TF. Effect of seeing tobacco use in films on trying smoking among adolescents: cross sectional study. BMJ. 2001 Dec 15;323(7326):1394-7. doi: 10.1136/bmj.323.7326.1394.
Reference Type
BACKGROUND
Dalton MA, Sargent JD, Beach ML, Titus-Ernstoff L, Gibson JJ, Ahrens MB, Tickle JJ, Heatherton TF. Effect of viewing smoking in movies on adolescent smoking initiation: a cohort study. Lancet. 2003 Jul 26;362(9380):281-5. doi: 10.1016/S0140-6736(03)13970-0.
Reference Type
BACKGROUND
Distefan JM, Pierce JP, Gilpin EA. Do favorite movie stars influence adolescent smoking initiation? Am J Public Health. 2004 Jul;94(7):1239-44. doi: 10.2105/ajph.94.7.1239.
Reference Type
BACKGROUND
Jackson C, Brown JD, L'Engle KL. R-rated movies, bedroom televisions, and initiation of smoking by white and black adolescents. Arch Pediatr Adolesc Med. 2007 Mar;161(3):260-8. doi: 10.1001/archpedi.161.3.260.
Reference Type
BACKGROUND
Barnett TE, Soule EK, Forrest JR, Porter L, Tomar SL. Adolescent Electronic Cigarette Use: Associations With Conventional Cigarette and Hookah Smoking. Am J Prev Med. 2015 Aug;49(2):199-206. doi: 10.1016/j.amepre.2015.02.013. Epub 2015 Mar 31.
Reference Type
BACKGROUND
Wills TA, Knight R, Williams RJ, Pagano I, Sargent JD. Risk factors for exclusive e-cigarette use and dual e-cigarette use and tobacco use in adolescents. Pediatrics. 2015 Jan;135(1):e43-51. doi: 10.1542/peds.2014-0760. Epub 2014 Dec 15.
Reference Type
BACKGROUND
Lochbuehler K, Otten R, Voogd H, Engels RC. Parental smoking and children's attention to smoking cues. J Psychopharmacol. 2012 Jul;26(7):1010-6. doi: 10.1177/0269881112439254. Epub 2012 Feb 27.
Reference Type
BACKGROUND
Kersbergen I, Field M. Visual attention to alcohol cues and responsible drinking statements within alcohol advertisements and public health campaigns: Relationships with drinking intentions and alcohol consumption in the laboratory. Psychol Addict Behav. 2017 Jun;31(4):435-446. doi: 10.1037/adb0000284. Epub 2017 May 11.
Reference Type
BACKGROUND
Yoshida, E., Peach, J. M., Zanna, M. P. & Spencer, S. J. Not all automatic associations are created equal: How implicit normative evaluations are distinct from implicit attitudes and uniquely predict meaningful behavior. J Exp Soc Psychol 48, 694-706 (2012).
Reference Type
BACKGROUND
Andrews JA, Hampson SE, Greenwald AG, Gordon J, Widdop C. Using the Implicit Association Test to Assess Children's Implicit Attitudes toward Smoking. J Appl Soc Psychol. 2010 Sep;40(9):2387-2406. doi: 10.1111/j.1559-1816.2010.00663.x.
Reference Type
BACKGROUND
Hine DW, Honan CA, Marks AD, Brettschneider K. Development and validation of the Smoking Expectancy Scale for Adolescents. Psychol Assess. 2007 Sep;19(3):347-55. doi: 10.1037/1040-3590.19.3.347.
Reference Type
BACKGROUND
Gilbert-Diamond D, Emond JA, Lansigan RK, Rapuano KM, Kelley WM, Heatherton TF, Sargent JD. Television food advertisement exposure and FTO rs9939609 genotype in relation to excess consumption in children. Int J Obes (Lond). 2017 Jan;41(1):23-29. doi: 10.1038/ijo.2016.163. Epub 2016 Sep 22.
Reference Type
BACKGROUND
Bernhardt AM, Wilking C, Gottlieb M, Emond J, Sargent JD. Children's reaction to depictions of healthy foods in fast-food television advertisements. JAMA Pediatr. 2014 May;168(5):422-6. doi: 10.1001/jamapediatrics.2014.140.
Reference Type
BACKGROUND
Gilbert, D. G. & Rabinovich, N. E. International smoking series (with neural counterparts) verion 1.2. (1999).
Reference Type
BACKGROUND
Macy JT, Chassin L, Presson CC, Yeung E. Exposure to graphic warning labels on cigarette packages: Effects on implicit and explicit attitudes towards smoking among young adults. Psychol Health. 2016;31(3):349-63. doi: 10.1080/08870446.2015.1104309. Epub 2015 Nov 3.
Reference Type
BACKGROUND
Wahl SK, Turner LR, Mermelstein RJ, Flay BR. Adolescents' smoking expectancies: psychometric properties and prediction of behavior change. Nicotine Tob Res. 2005 Aug;7(4):613-23. doi: 10.1080/14622200500185579.
Reference Type
BACKGROUND
Sargent JD, Worth KA, Beach M, Gerrard M, Heatherton TF. Population-Based Assessment of Exposure to Risk Behaviors in Motion Pictures. Commun Methods Meas. 2008 Jan;2(1-2):134-151. doi: 10.1080/19312450802063404.
Reference Type
BACKGROUND
Lochbuehler K, Voogd H, Scholte RH, Engels RC. Attentional bias in smokers: exposure to dynamic smoking cues in contemporary movies. J Psychopharmacol. 2011 Apr;25(4):514-9. doi: 10.1177/0269881110388325. Epub 2010 Nov 23.
Reference Type
BACKGROUND
Connor CE, Egeth HE, Yantis S. Visual attention: bottom-up versus top-down. Curr Biol. 2004 Oct 5;14(19):R850-2. doi: 10.1016/j.cub.2004.09.041.
Reference Type
BACKGROUND
Dalton MA, Sargent JD, Beach ML, Bernhardt AM, Stevens M. Positive and negative outcome expectations of smoking: implications for prevention. Prev Med. 1999 Dec;29(6 Pt 1):460-5. doi: 10.1006/pmed.1999.0582.
Reference Type
BACKGROUND
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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D19034
Identifier Type: -
Identifier Source: org_study_id
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