Acute Effects of E-Cigarette Aerosol Inhalation

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-22

Study Completion Date

2022-08-31

Brief Summary

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This study comprises a portion of a larger study designed to compare results of vascular function in non-smokers to vascular function in healthy smokers chronically exposed to nicotinized electronic cigarette aerosol versus conventional cigarettes.

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Detailed Description

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Here, we 1) investigate the acute effects of non-nicotinized e-cigarette aerosol inhalation in nonsmokers in terms of blood-based markers of inflammation and oxidative stress, and 2) evaluate their association with hemodynamic-metabolic MRI parameters quantifying peripheral vascular reactivity, cerebrovascular reactivity, and aortic stiffness.

Conditions

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Endothelial Dysfunction Biochemical Markers

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Healthy, Non-Smokers

Non-nicotinized electronic cigarette aerosol (16 2-second long puffs)

Group Type EXPERIMENTAL

Electronic Cigarette Aerosol

Intervention Type DRUG

16 two-second-long puffs from a non-nicotinized electronic cigarette.

Interventions

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Electronic Cigarette Aerosol

16 two-second-long puffs from a non-nicotinized electronic cigarette.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

• BMI of 18.5 - 30

Exclusion Criteria

* Cancer
* HIV
* Mental illness
* Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks)
* Serious arrhythmias
* Bronchospastic disease
* Upper respiratory tract infection within the past six weeks
* Chronic medication or antibiotics
* Claustrophobia / contraindications for MRI

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes