Fatty Acid Composition of Subcutaneous Adipose Tissue in Infants: A Prospective and Observational Study
NCT ID: NCT03785990
Last Updated: 2018-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
21 participants
OBSERVATIONAL
2017-04-03
2019-10-31
Brief Summary
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Detailed Description
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* subcutaneous adipose tissue of term infants and preterms after birth and at term during a clinically indicated operation.
* blood before the operation.
Measurement of the fatty acid composition (especially arachidonic acid and docosahexaenoic acid) in subcutaneous adipose tissue and blood.
Aim is to compare the composition of the fatty acids in blood and adipose tissue of preterms at term and term infants. To calculate the fatty acid value in each infant the proportion of adipose tissue is determined with PEAPOD before discharge from hospital.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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preterms with enterostomy
GA 23±0/7 - 31±6/7 with clinically indicated operations because of NEC (necrotising enterocolitis) or FIP (focal intestinal perforation). Operation after birth (within 14 days) and at term (enterostomy closure) Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)
adipose tissue
taking a sample of the adipose tissue during operation
blood
taking a blood sample when a peripheral venous catheter is inserted before operation
PEAPOD
Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy)
preterms without enterostomy
GA 23±0/7 bis 31±6/7 with a clinically indicated operation (e.g. herniotomy) at term, without any abdominal problems.
Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)
adipose tissue
taking a sample of the adipose tissue during operation
blood
taking a blood sample when a peripheral venous catheter is inserted before operation
PEAPOD
Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy)
term infants
GA ≥34±0/7 with a clinically indicated operation directly after birth (within 14 days) (e.g. gastroschisis).
Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)
adipose tissue
taking a sample of the adipose tissue during operation
blood
taking a blood sample when a peripheral venous catheter is inserted before operation
PEAPOD
Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy)
Interventions
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adipose tissue
taking a sample of the adipose tissue during operation
blood
taking a blood sample when a peripheral venous catheter is inserted before operation
PEAPOD
Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* genetic diseases
* missing agreement for the study
6 Months
ALL
No
Sponsors
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University Hospital Tuebingen
OTHER
Responsible Party
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Principal Investigators
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Axel Franz
Role: PRINCIPAL_INVESTIGATOR
University Hospital Tuebingen
Locations
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University Hospital of Tuebingen
Tübingen, , Germany
Countries
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Central Contacts
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Facility Contacts
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Axel R Franz, MD
Role: primary
References
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Bockmann KA, von Stumpff A, Bernhard W, Shunova A, Minarski M, Frische B, Warmann S, Schleicher E, Poets CF, Franz AR. Fatty acid composition of adipose tissue at term indicates deficiency of arachidonic and docosahexaenoic acid and excessive linoleic acid supply in preterm infants. Eur J Nutr. 2021 Mar;60(2):861-872. doi: 10.1007/s00394-020-02293-2. Epub 2020 May 31.
Other Identifiers
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NEO-Adipose tissue
Identifier Type: -
Identifier Source: org_study_id