Isometric Exercise and Endogenous Pain Inhibition

NCT ID: NCT03778476

Last Updated: 2021-02-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 43 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-05-25
• Study Completion Date: 2019-10-29

Brief Summary

The purpose of this study is to identify the acute effects of isometric exercise on the inhibition of pain in individuals with fibromyalgia.

Detailed Description

Fibromyalgia syndrome (FMS) is a chronic pain condition that is characterized by widespread pain which affects 5-8% of the general population. Past research has shown that people with FMS demonstrate enhanced pain facilitation and reduced pain inhibition in the central nervous system. Incorporating a biopsychosocial model of pain may help develop strategies to prevent the functional decline and alleviate the suffering that occurs in this population. Exercise is a mainstay of pain rehabilitation with multiple health benefits, one of which is decreasing pain; a phenomenon known as exercise induced hypoalgesia (EIH). Emerging evidence has shown that exercise decreases pain facilitation in healthy adults and in some individuals with FMS. However, it's unclear whether exercise improves pain inhibition in individuals with FMS. The purpose of this study is to investigate endogenous pain inhibition, measured by conditioned pain modulation (CPM), following isometric exercise of the quadriceps muscle in individuals with FMS. In addition, factors that might affect this response such as physical activity, body composition, and psychosocial issues will be examined. Understanding how exercise impacts pain and the contributing factors will help guide the prescription of exercise to optimize pain rehabilitation.

Conditions

Fibromyalgia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Isometric Exercise

Participants will perform a submaximal voluntary contraction of the quadriceps muscle to task failure.

Group Type: EXPERIMENTAL

Isometric Exercise

Intervention Type: OTHER

Participants will be asked to hold a submaximal voluntary contraction of the quadriceps muscle as long as they can (task failure).

Quiet Rest

Participants will sit quietly for a period of time that mimics the exercise.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Isometric Exercise

Participants will be asked to hold a submaximal voluntary contraction of the quadriceps muscle as long as they can (task failure).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Men and women aged 18-75 diagnosed with fibromyalgia or healthy controls will be included in the study.

Exclusion Criteria

• cardiovascular disease, cancer, pregnancy, arthritis, diabetes, claustrophobia, Reynaud's disease, osteoporosis, neuropathy.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Marquette University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marie Hoeger Bement, PT, PhD

Role: PRINCIPAL_INVESTIGATOR

Marquette University

Ali Alsouhibani, PT, MS

Role: STUDY_DIRECTOR

Marquette University

Locations

Marquette University

Milwaukee, Wisconsin, United States

Countries

United States

Other Identifiers

HR3035

Identifier Type: -

Identifier Source: org_study_id