The Effect of Water Intake on Glucose Regulation

NCT ID: NCT03765008

Last Updated: 2019-08-28

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-02-11
• Study Completion Date: 2019-04-29

Brief Summary

There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.

In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation

Conditions

Glucose Metabolism Disorders; Dehydration (Physiology); Water Deprivation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

High Water intake

5-days of High water intake according to IOM guidelines

Group Type: ACTIVE_COMPARATOR

Water intake manipulation

Intervention Type: OTHER

for 5 days prior to each experiment subjects will undergo manipulation of their water intake.

Low Water Intake

5-days of Low water intake of 500 mL/day

Group Type: EXPERIMENTAL

Water intake manipulation

Intervention Type: OTHER

for 5 days prior to each experiment subjects will undergo manipulation of their water intake.

Interventions

Water intake manipulation

for 5 days prior to each experiment subjects will undergo manipulation of their water intake.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

BMI 27.5-35

Exclusion Criteria

• BMI <27.5 or >35
• high physical activity
• diabetes
• impaired liver or kidney function
• cardiovascular disease
• weight change of more than 3 kg in the past month
• pregnancy
• previous surgery on digestive tract (except appendectomy)
• fluid balance will be exclusionary such as
• serotonin re-uptake inhibitors.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Arizona State University

OTHER

Sponsor Role: lead

Responsible Party

Stavros Kavouras

Professor of Nutrition

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

FP00018531

Identifier Type: -

Identifier Source: org_study_id