The Aim of This Project is to Verify Whether a Depletion of B Cell Memory Subpopulation ("Marginal-zone-like") CD19 + IgD + CD27 + and CD19 + IgM + CD27 + is a Useful Indicator of Hyposplenism in Patients With Celiac Disease
NCT ID: NCT03763487
Last Updated: 2018-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2018-06-01
2018-12-31
Brief Summary
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Other objectives of project are:
* determination of gliadin 33-mer in faecal and urine as indicators patient´s adherence to gluten-free diet
* determination of citrulline in plasma as an indicator of the overall functional capacity enterocytes
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Patients
Ultrasound examination: scaled to spleen size (spleen volumetry) Methodology of laboratory tests: venous blood sampling
venous blood sampling
Venous blood samples to determine memory B lymphocytes.
spleen volumetry
Ultrasound examination of spleen to scaled the size.
healthy blood donors
No intervention in this group.
No interventions assigned to this group
Interventions
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venous blood sampling
Venous blood samples to determine memory B lymphocytes.
spleen volumetry
Ultrasound examination of spleen to scaled the size.
Eligibility Criteria
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Inclusion Criteria
* age over 18 years
Exclusion Criteria
* infectious and non-infectious inflammation of the small intestine
* congenital or acquired immunodeficiency
* autoimmune disease
* immunosuppressant treatment
* diabetes mellitus
* pregnancy and lactation
18 Years
ALL
No
Sponsors
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University Hospital Hradec Kralove
OTHER
Responsible Party
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Proff. Jan Bures, MD
Principal Investigator
Locations
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University Hospital Hradec Králové
Hradec Králové, The Czech Republic, Czechia
Countries
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Central Contacts
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Facility Contacts
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Related Links
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Related Info
Related Info
Other Identifiers
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Indicators of celiac activity
Identifier Type: -
Identifier Source: org_study_id
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