Non-Invasive Monitoring of Partial Pressure of Carbon Dioxide in Mechanically Ventilated Preterm Infants
NCT ID: NCT03758313
Last Updated: 2021-08-17
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Total Enrollment
27 participants
Study Classification
OBSERVATIONAL
Study Start Date
2018-11-01
Study Completion Date
2020-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
In mechanically ventilated preterm infants, the ability to monitor carbon dioxide partial pressure (pCO2) values is indispensable. The gold standard for pCO2 measurement is from an arterial blood sample (paCO2). This has two drawbacks: firstly, it requires an arterial line and, secondly, it does not provide the clinicians with a continuous measurement. At present, two alternative pCO2 monitoring systems are available in the field of neonatal intensive care medicine: end-tidal CO2 (etCO2) capnography and transcutaneous CO2 (tcCO2) measurements. Both methods have disadvantages including potential technical errors as well as pathologies that may reduce reliability as a surrogate for blood gas analysis (BGA). In particular, conventional side-stream etCO2 capnography underestimates pCO2 in presence of a tube leakage, which is a common occurrence in ventilated preterm infants where only tubes without cuff are used. Distal etCO2 (detCO2) by means of a double lumen endo-tracheal tube may solve the problem of unreliable etCO2 values in the presence of tube leakage.
The aim of this study is to compare the agreement, precision and repeatability of the distal etCO2-measurement technique described by Kugelman et al. with respect to paCO2 and tcCO2 in mechanically ventilated preterm infants. Since ventilation strategies and pCO2 limits may vary among different centers, this study helps to determine which non-invasive CO2 monitoring system (detCO2 or tcO2) is more suitable in terms of applicability and reliability in preterm infants at our neonatal intensive care units.
The aim of this study is to compare the agreement, precision and repeatability of the distal etCO2-measurement technique described by Kugelman et al. with respect to paCO2 and tcCO2 in mechanically ventilated preterm infants. Since ventilation strategies and pCO2 limits may vary among different centers, this study helps to determine which non-invasive CO2 monitoring system (detCO2 or tcO2) is more suitable in terms of applicability and reliability in preterm infants at our neonatal intensive care units.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Co2 Monitoring at Preterm Delivery-Observational Study
NCT04699708
Resuscitation
UNKNOWN
Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study
NCT07251790
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome in Premature Infant
NOT_YET_RECRUITING
NA
Non-invasive Support in Extremely Preterm Infants
NCT02723123
Noninvasive Ventilation
UNKNOWN
NA
Respiratory Dynamics During Birth Stabilization in Preterm Infants Less Than 32+6/7 Weeks Gestation
NCT02748720
Infant, Premature
COMPLETED
NA
Automatic Oxygen Control (SPOC) in Preterm Infants
NCT03785899
Infantile Respiratory Distress Syndrome
Ventilator Lung; Newborn
UNKNOWN
NA
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Background: In mechanically ventilated preterm infants, the ability to monitor carbon dioxide partial pressure (pCO2) values is indispensable. The gold standard for pCO2 measurement is from an arterial blood sample (paCO2). This has two drawbacks: firstly, it requires an arterial line and, secondly, it does not provide the clinicians with a continuous measurement. At present, two alternative pCO2 monitoring systems are available in the field of neonatal intensive care medicine: end-tidal CO2 (etCO2) capnography and transcutaneous CO2 (tcCO2) measurements. Both methods have disadvantages including potential technical errors as well as pathologies that may reduce reliability as a surrogate for blood gas analysis (BGA). In particular, conventional side-stream etCO2 capnography underestimates pCO2 in presence of a tube leakage, which is a common occurrence in ventilated preterm infants where only tubes without cuff are used. Distal etCO2 (detCO2) by means of a double lumen endo-tracheal tube may solve the problem of unreliable etCO2 values in the presence of tube leakage.
Several studies compared etCO2 and tcCO2 to paCO2, simultaneously. A comparison study of etCO2 and tcCO2 in a cohort of critically ill children did not reveal significant differences in the absence of severe pulmonary parenchymal disease. Tobias et al compared etCO2 and tcCO2 in a cohort of pediatric intensive care patients with respiratory failure and found tcCO2 measurements to be more accurate. In a cohort of ventilated newborns, tcCO2 monitoring was generally more precise than etCO2 during neonatal transport to monitor ventilation. In a more recent study restricted to a cohort of postsurgical neonates without lung disease, etCO2 underestimated paCO2 more than tcCO2 but provided greater precision over paCO2, however it was less accurate at smaller tidal volumes. These studies have in common that the adapter of the pCO2 analyzer was attached in-line and proximal to the endotracheal tube.
Aim of the study: The aim of this study is to compare the agreement, precision and repeatability of the distal etCO2-measurement technique described by Kugelman et al. with respect to paCO2 and tcCO2 in mechanically ventilated preterm infants. Since ventilation strategies and pCO2 limits may vary among different centers, this study helps to determine which non-invasive CO2 monitoring system (detCO2 or tcO2) is more suitable in terms of applicability and reliability in preterm infants at our neonatal intensive care units.
Several studies compared etCO2 and tcCO2 to paCO2, simultaneously. A comparison study of etCO2 and tcCO2 in a cohort of critically ill children did not reveal significant differences in the absence of severe pulmonary parenchymal disease. Tobias et al compared etCO2 and tcCO2 in a cohort of pediatric intensive care patients with respiratory failure and found tcCO2 measurements to be more accurate. In a cohort of ventilated newborns, tcCO2 monitoring was generally more precise than etCO2 during neonatal transport to monitor ventilation. In a more recent study restricted to a cohort of postsurgical neonates without lung disease, etCO2 underestimated paCO2 more than tcCO2 but provided greater precision over paCO2, however it was less accurate at smaller tidal volumes. These studies have in common that the adapter of the pCO2 analyzer was attached in-line and proximal to the endotracheal tube.
Aim of the study: The aim of this study is to compare the agreement, precision and repeatability of the distal etCO2-measurement technique described by Kugelman et al. with respect to paCO2 and tcCO2 in mechanically ventilated preterm infants. Since ventilation strategies and pCO2 limits may vary among different centers, this study helps to determine which non-invasive CO2 monitoring system (detCO2 or tcO2) is more suitable in terms of applicability and reliability in preterm infants at our neonatal intensive care units.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Preterm Infant
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
CO2 measurements
Distal etCO2, tcCO2 and paCO2 values will be recorded simultaneously in ventilated preterm infants. We will measure etCO2 in a distal position using a double lumen tube connected to an external side-stream capnometer.
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Preterm infants with a current body weight between 1000 g and 3000 g who require intubation.
* Signed informed consent from parents or legal guardians.
* Expected to provide at least three measurements of paCO2 and detCO2.
* Signed informed consent from parents or legal guardians.
* Expected to provide at least three measurements of paCO2 and detCO2.
Exclusion Criteria
* Infants with known congenital anomalies of the heart and/or lung.
* Need for high frequency oscillation.
* Parents or legal guardians deny informed consent.
* Need for high frequency oscillation.
* Parents or legal guardians deny informed consent.
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Tobias Werther
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Tobias Werther
Dr.
Responsibility Role
SPONSOR_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Tobias Werther, PhD
Role: PRINCIPAL_INVESTIGATOR
Medical University Vienna
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Department of Pediatrics, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna
Vienna, , Austria
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Austria
References
Explore related publications, articles, or registry entries linked to this study.
Tobias JD. Transcutaneous carbon dioxide monitoring in infants and children. Paediatr Anaesth. 2009 May;19(5):434-44. doi: 10.1111/j.1460-9592.2009.02930.x. Epub 2009 Feb 19.
Reference Type
BACKGROUND
Aliwalas LL, Noble L, Nesbitt K, Fallah S, Shah V, Shah PS. Agreement of carbon dioxide levels measured by arterial, transcutaneous and end tidal methods in preterm infants < or = 28 weeks gestation. J Perinatol. 2005 Jan;25(1):26-9. doi: 10.1038/sj.jp.7211202.
Reference Type
BACKGROUND
Molloy EJ, Deakins K. Are carbon dioxide detectors useful in neonates? Arch Dis Child Fetal Neonatal Ed. 2006 Jul;91(4):F295-8. doi: 10.1136/adc.2005.082008.
Reference Type
BACKGROUND
McDonald MJ, Montgomery VL, Cerrito PB, Parrish CJ, Boland KA, Sullivan JE. Comparison of end-tidal CO2 and Paco2 in children receiving mechanical ventilation. Pediatr Crit Care Med. 2002 Jul;3(3):244-249. doi: 10.1097/00130478-200207000-00008.
Reference Type
BACKGROUND
Schmalisch G. Current methodological and technical limitations of time and volumetric capnography in newborns. Biomed Eng Online. 2016 Aug 30;15(1):104. doi: 10.1186/s12938-016-0228-4.
Reference Type
BACKGROUND
Anderson CT, Breen PH. Carbon dioxide kinetics and capnography during critical care. Crit Care. 2000;4(4):207-15. doi: 10.1186/cc696. Epub 2000 Jul 12.
Reference Type
BACKGROUND
Wu CH, Chou HC, Hsieh WS, Chen WK, Huang PY, Tsao PN. Good estimation of arterial carbon dioxide by end-tidal carbon dioxide monitoring in the neonatal intensive care unit. Pediatr Pulmonol. 2003 Apr;35(4):292-5. doi: 10.1002/ppul.10260.
Reference Type
BACKGROUND
Amuchou Singh S, Singhal N. Dose end-tidal carbon dioxide measurement correlate with arterial carbon dioxide in extremely low birth weight infants in the first week of life? Indian Pediatr. 2006 Jan;43(1):20-5.
Reference Type
BACKGROUND
Dargaville PA, Tingay DG. Lung protective ventilation in extremely preterm infants. J Paediatr Child Health. 2012 Sep;48(9):740-6. doi: 10.1111/j.1440-1754.2012.02532.x.
Reference Type
BACKGROUND
Keszler M, Nassabeh-Montazami S, Abubakar K. Evolution of tidal volume requirement during the first 3 weeks of life in infants <800 g ventilated with Volume Guarantee. Arch Dis Child Fetal Neonatal Ed. 2009 Jul;94(4):F279-82. doi: 10.1136/adc.2008.147157. Epub 2008 Dec 5.
Reference Type
BACKGROUND
Nassabeh-Montazami S, Abubakar KM, Keszler M. The impact of instrumental dead-space in volume-targeted ventilation of the extremely low birth weight (ELBW) infant. Pediatr Pulmonol. 2009 Feb;44(2):128-33. doi: 10.1002/ppul.20954.
Reference Type
BACKGROUND
Hagerty JJ, Kleinman ME, Zurakowski D, Lyons AC, Krauss B. Accuracy of a new low-flow sidestream capnography technology in newborns: a pilot study. J Perinatol. 2002 Apr-May;22(3):219-25. doi: 10.1038/sj.jp.7210672.
Reference Type
BACKGROUND
Nangia S, Saili A, Dutta AK. End tidal carbon dioxide monitoring--its reliability in neonates. Indian J Pediatr. 1997 May-Jun;64(3):389-94. doi: 10.1007/BF02845211.
Reference Type
BACKGROUND
Singh BS, Gilbert U, Singh S, Govindaswami B. Sidestream microstream end tidal carbon dioxide measurements and blood gas correlations in neonatal intensive care unit. Pediatr Pulmonol. 2013 Mar;48(3):250-6. doi: 10.1002/ppul.22593. Epub 2012 May 15.
Reference Type
BACKGROUND
Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB; COIN Trial Investigators. Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med. 2008 Feb 14;358(7):700-8. doi: 10.1056/NEJMoa072788.
Reference Type
BACKGROUND
Giannakopoulou C, Korakaki E, Manoura A, Bikouvarakis S, Papageorgiou M, Gourgiotis D, Hatzidaki E. Significance of hypocarbia in the development of periventricular leukomalacia in preterm infants. Pediatr Int. 2004 Jun;46(3):268-73. doi: 10.1111/j.1442-200x.2004.01886.x.
Reference Type
BACKGROUND
Erickson SJ, Grauaug A, Gurrin L, Swaminathan M. Hypocarbia in the ventilated preterm infant and its effect on intraventricular haemorrhage and bronchopulmonary dysplasia. J Paediatr Child Health. 2002 Dec;38(6):560-2. doi: 10.1046/j.1440-1754.2002.00041.x.
Reference Type
BACKGROUND
Mahmoud RA, Proquitte H, Fawzy N, Buhrer C, Schmalisch G. Tracheal tube airleak in clinical practice and impact on tidal volume measurement in ventilated neonates. Pediatr Crit Care Med. 2011 Mar;12(2):197-202. doi: 10.1097/PCC.0b013e3181e89834.
Reference Type
BACKGROUND
Schmalisch G, Al-Gaaf S, Proquitte H, Roehr CC. Effect of endotracheal tube leak on capnographic measurements in a ventilated neonatal lung model. Physiol Meas. 2012 Oct;33(10):1631-41. doi: 10.1088/0967-3334/33/10/1631. Epub 2012 Sep 18.
Reference Type
BACKGROUND
Proquitte H, Krause S, Rudiger M, Wauer RR, Schmalisch G. Current limitations of volumetric capnography in surfactant-depleted small lungs. Pediatr Crit Care Med. 2004 Jan;5(1):75-80. doi: 10.1097/01.PCC.0000102384.60676.E5.
Reference Type
BACKGROUND
Kugelman A, Golan A, Riskin A, Shoris I, Ronen M, Qumqam N, Bader D, Bromiker R. Impact of Continuous Capnography in Ventilated Neonates: A Randomized, Multicenter Study. J Pediatr. 2016 Jan;168:56-61.e2. doi: 10.1016/j.jpeds.2015.09.051. Epub 2015 Oct 17.
Reference Type
BACKGROUND
Kugelman A, Zeiger-Aginsky D, Bader D, Shoris I, Riskin A. A novel method of distal end-tidal CO2 capnography in intubated infants: comparison with arterial CO2 and with proximal mainstream end-tidal CO2. Pediatrics. 2008 Dec;122(6):e1219-24. doi: 10.1542/peds.2008-1300. Epub 2008 Nov 24.
Reference Type
BACKGROUND
Cassady G. Transcutaneous monitoring in the newborn infant. J Pediatr. 1983 Dec;103(6):837-48. doi: 10.1016/s0022-3476(83)80698-2. No abstract available.
Reference Type
BACKGROUND
Rennie JM. Transcutaneous carbon dioxide monitoring. Arch Dis Child. 1990 Apr;65(4 Spec No):345-6. doi: 10.1136/adc.65.4_spec_no.345. No abstract available.
Reference Type
BACKGROUND
Bendjelid K, Schutz N, Stotz M, Gerard I, Suter PM, Romand JA. Transcutaneous PCO2 monitoring in critically ill adults: clinical evaluation of a new sensor. Crit Care Med. 2005 Oct;33(10):2203-6. doi: 10.1097/01.ccm.0000181734.26070.26.
Reference Type
BACKGROUND
Dullenkopf A, Bernardo SD, Berger F, Fasnacht M, Gerber AC, Weiss M. Evaluation of a new combined SpO2/PtcCO2 sensor in anaesthetized paediatric patients. Paediatr Anaesth. 2003 Nov;13(9):777-84. doi: 10.1046/j.1460-9592.2003.01146.x.
Reference Type
BACKGROUND
Sorensen LC, Brage-Andersen L, Greisen G. Effects of the transcutaneous electrode temperature on the accuracy of transcutaneous carbon dioxide tension. Scand J Clin Lab Invest. 2011 Nov;71(7):548-52. doi: 10.3109/00365513.2011.590601. Epub 2011 Jul 6.
Reference Type
BACKGROUND
Eberhard P. The design, use, and results of transcutaneous carbon dioxide analysis: current and future directions. Anesth Analg. 2007 Dec;105(6 Suppl):S48-S52. doi: 10.1213/01.ane.0000278642.16117.f8.
Reference Type
BACKGROUND
Hirata K, Nishihara M, Oshima Y, Hirano S, Kitajima H. Application of transcutaneous carbon dioxide tension monitoring with low electrode temperatures in premature infants in the early postnatal period. Am J Perinatol. 2014 May;31(5):435-40. doi: 10.1055/s-0033-1352485. Epub 2013 Aug 5.
Reference Type
BACKGROUND
Aly S, El-Dib M, Mohamed M, Aly H. Transcutaneous Carbon Dioxide Monitoring with Reduced-Temperature Probes in Very Low Birth Weight Infants. Am J Perinatol. 2017 Apr;34(5):480-485. doi: 10.1055/s-0036-1593352. Epub 2016 Sep 27.
Reference Type
BACKGROUND
Karlsson V, Sporre B, Agren J. Transcutaneous PCO2 Monitoring in Newborn Infants During General Anesthesia Is Technically Feasible. Anesth Analg. 2016 Oct;123(4):1004-7. doi: 10.1213/ANE.0000000000001462.
Reference Type
BACKGROUND
Restrepo RD, Hirst KR, Wittnebel L, Wettstein R. AARC clinical practice guideline: transcutaneous monitoring of carbon dioxide and oxygen: 2012. Respir Care. 2012 Nov;57(11):1955-62. doi: 10.4187/respcare.02011.
Reference Type
BACKGROUND
Sivan Y, Eldadah MK, Cheah TE, Newth CJ. Estimation of arterial carbon dioxide by end-tidal and transcutaneous PCO2 measurements in ventilated children. Pediatr Pulmonol. 1992 Mar;12(3):153-7. doi: 10.1002/ppul.1950120305.
Reference Type
BACKGROUND
Tobias JD, Meyer DJ. Noninvasive monitoring of carbon dioxide during respiratory failure in toddlers and infants: end-tidal versus transcutaneous carbon dioxide. Anesth Analg. 1997 Jul;85(1):55-8. doi: 10.1097/00000539-199707000-00010.
Reference Type
BACKGROUND
Tingay DG, Stewart MJ, Morley CJ. Monitoring of end tidal carbon dioxide and transcutaneous carbon dioxide during neonatal transport. Arch Dis Child Fetal Neonatal Ed. 2005 Nov;90(6):F523-6. doi: 10.1136/adc.2004.064717. Epub 2005 Apr 29.
Reference Type
BACKGROUND
Tingay DG, Mun KS, Perkins EJ. End tidal carbon dioxide is as reliable as transcutaneous monitoring in ventilated postsurgical neonates. Arch Dis Child Fetal Neonatal Ed. 2013 Mar;98(2):F161-4. doi: 10.1136/fetalneonatal-2011-301606. Epub 2012 Aug 11.
Reference Type
BACKGROUND
van Kaam AH, De Jaegere AP, Rimensberger PC; Neovent Study Group. Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants. Arch Dis Child Fetal Neonatal Ed. 2013 Jul;98(4):F323-6. doi: 10.1136/archdischild-2012-302649. Epub 2012 Dec 14.
Reference Type
BACKGROUND
Donner A, Eliasziw M. Sample size requirements for reliability studies. Stat Med. 1987 Jun;6(4):441-8. doi: 10.1002/sim.4780060404.
Reference Type
BACKGROUND
Muller R, Buttner P. A critical discussion of intraclass correlation coefficients. Stat Med. 1994 Dec 15-30;13(23-24):2465-76. doi: 10.1002/sim.4780132310.
Reference Type
BACKGROUND
Walter SD, Eliasziw M, Donner A. Sample size and optimal designs for reliability studies. Stat Med. 1998 Jan 15;17(1):101-10. doi: 10.1002/(sici)1097-0258(19980115)17:13.0.co;2-e.
Reference Type
BACKGROUND
McSwain SD, Hamel DS, Smith PB, Gentile MA, Srinivasan S, Meliones JN, Cheifetz IM. End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space. Respir Care. 2010 Mar;55(3):288-93.
Reference Type
BACKGROUND
Siobal MS. Monitoring Exhaled Carbon Dioxide. Respir Care. 2016 Oct;61(10):1397-416. doi: 10.4187/respcare.04919. Epub 2016 Sep 6.
Reference Type
BACKGROUND
Fayoux P, Devisme L, Merrot O, Marciniak B. Determination of endotracheal tube size in a perinatal population: an anatomical and experimental study. Anesthesiology. 2006 May;104(5):954-60. doi: 10.1097/00000542-200605000-00011.
Reference Type
BACKGROUND
Yildizdas D, Yapicioglu H, Yilmaz HL, Sertdemir Y. Correlation of simultaneously obtained capillary, venous, and arterial blood gases of patients in a paediatric intensive care unit. Arch Dis Child. 2004 Feb;89(2):176-80. doi: 10.1136/adc.2002.016261.
Reference Type
BACKGROUND
Zavorsky GS, Cao J, Mayo NE, Gabbay R, Murias JM. Arterial versus capillary blood gases: a meta-analysis. Respir Physiol Neurobiol. 2007 Mar 15;155(3):268-79. doi: 10.1016/j.resp.2006.07.002. Epub 2006 Aug 17.
Reference Type
BACKGROUND
Bland JM, Altman DG. Agreement between methods of measurement with multiple observations per individual. J Biopharm Stat. 2007;17(4):571-82. doi: 10.1080/10543400701329422.
Reference Type
BACKGROUND
Werther T, Aichhorn L, Stellberg S, Cardona FS, Klebermass-Schrehof K, Berger A, Schmolzer GM, Wagner M. Monitoring of carbon dioxide in ventilated neonates: a prospective observational study. Arch Dis Child Fetal Neonatal Ed. 2022 May;107(3):293-298. doi: 10.1136/archdischild-2021-322138. Epub 2021 Aug 3.
Reference Type
DERIVED
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
1173/2018
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Haemodynamic Changes With Different Noninvasive Respiratory Modes for Primary Respiratory Support in Preterm Neonates
NCT06737003
COMPLETED
NA
Speed of Lung Inflation During Ventilation of Extremely Preterm Infants
NCT07101419
NOT_YET_RECRUITING
NA
Monitoring Neonatal Resuscitation Trial
NCT03256578
COMPLETED
NA
Cerebral Oxygenation in Preterm Neonates with Respiratory Support During Skin-to-skin Care on the First Day After Birth
NCT04865302
COMPLETED
Transcutaneous Partial Oxygen and Carbon Dioxide Pressures Compared With Blood Gas Values
NCT03060018
COMPLETED
NA
The Role of Circuit Flow During Mechanical Ventilation of Neonates
NCT03306524
COMPLETED
NA
Optimal Settings of Non Invasive Respiratory Support in Preterm Newborns
NCT03592134
UNKNOWN
Impact of Synchronized Nasal Intermittent Positive Pressure Ventilation Using NAVA in Preterm Infants With RDS
NCT02030652
UNKNOWN
NA
Non-invasive Neurally Adjusted Ventilator Assist or Continuous Positive Airway Pressure in Preterm Infants
NCT04333563
COMPLETED
NA
Pressure-Sensing Mattresses and Mechanical Ventilation Weaning in Neonatal
NCT06579157
RECRUITING
Neural Control of Non-invasive Ventilation in the Preterm
NCT00368485
COMPLETED
PHASE1
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
NCT03168516
ACTIVE_NOT_RECRUITING
PHASE3
Non-invasive Ventilation in Preterm Infants
NCT05987800
ACTIVE_NOT_RECRUITING
NA
Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants
NCT02799875
COMPLETED
NA
Ventilatory Management of the Preterm Neonate in the Delivery Room
NCT01255826
COMPLETED
PHASE2
Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation
NCT07237139
RECRUITING
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
NCT04391634
COMPLETED
NA
nHFOV vs nCPAP: Effects on Gas Exchange for the Treatment of Neonates Recovering From RDS
NCT02772835
COMPLETED
NA
Early CPAP in Respiratory Distress Syndrome
NCT00368680
UNKNOWN
PHASE4
Repercussions of Respiratory Physiotherapy in Preterm Infants Under Mechanical Ventilation
NCT03159039
COMPLETED
NA
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
NCT02493920
WITHDRAWN
NA
Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room
NCT03938532
TERMINATED
NA
Cpap at Delivery Room for Preterm Infants
NCT01024361
UNKNOWN
PHASE4
Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 2
NCT03333161
COMPLETED
NA
Peripheral Fractional Tissue Oxygen Extraction and Infection in Term and Preterm Neonates
NCT04818762
RECRUITING