HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma

NCT ID: NCT03742869

Last Updated: 2018-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-10

Study Completion Date

2021-11-23

Brief Summary

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This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.

Detailed Description

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Conditions

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Cervical Adenocarcinoma Human Papillomavirus Genome-wide Association Study Whole Exome Sequencing Transcriptome Metabolome Tumorigenesis Prognosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with HPV integration

The HPV integration status will be checked by GWAS.

A multi-omics analysis

Intervention Type COMBINATION_PRODUCT

A multi-omics analysis including genome-wide association study, whole exome sequencing, transcriptomics and metabolomics.

Patients without HPV integration

The HPV integration status will be checked by GWAS.

A multi-omics analysis

Intervention Type COMBINATION_PRODUCT

A multi-omics analysis including genome-wide association study, whole exome sequencing, transcriptomics and metabolomics.

Interventions

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A multi-omics analysis

A multi-omics analysis including genome-wide association study, whole exome sequencing, transcriptomics and metabolomics.

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Confirmed primary adenocarcinoma of the uterine cervix
* Signed an approved informed consents
* Feasible for biopsy
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Lei Li

OTHER

Sponsor Role lead

Responsible Party

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Lei Li

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lei Li, M.D.

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

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Lei Li

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lei Li, M.D.

Role: CONTACT

13911988831 ext. 86

Facility Contacts

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Lei Li, MD

Role: primary

13911988831 ext. 86

Other Identifiers

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HITA

Identifier Type: -

Identifier Source: org_study_id

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