Hemostasis Achievement Reflecting Inflammatory Status of the Pulp Based on Cytokine Levels: A Cohort Study.

NCT ID: NCT03737682

Last Updated: 2024-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-07-30

Study Completion Date

2023-08-14

Brief Summary

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Assessment of pulp inflammation by hemostasis achievement after pulp exposure

Detailed Description

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The possibility has been raised of diagnosing pulpal pathological status using the cytokines that are released during the inflammation process in healthy as well as infected tooth pulp. Cytokines are small polypeptides secreted by leucocytes and other inflammatory cells and are known to play important roles in the intensity and duration of the immune response

Conditions

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Hemorrhage

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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hemostasis achievement

in which hemostasis at the exposure site was achieved in five minutes were included in group A

ENzyme linked immunity-sorbet assays

Intervention Type DIAGNOSTIC_TEST

Hemostasis achievement reflecting inflammatory status of the pulp based on cytokine levels

No hemostasis achievement

in which hemostasis at the exposure site couldn't be achieved in five minutes where included in group B

ENzyme linked immunity-sorbet assays

Intervention Type DIAGNOSTIC_TEST

Hemostasis achievement reflecting inflammatory status of the pulp based on cytokine levels

Interventions

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ENzyme linked immunity-sorbet assays

Hemostasis achievement reflecting inflammatory status of the pulp based on cytokine levels

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. healthy children
2. patients had not used any inflammatory medications
3. primary molar teeth of these children were included based on the following clinical and radiographic criteria:

1. no clinical symptoms or evidence of pulp degeneration (pain on percussion, history of swelling or sinus tract
2. no spontaneous pain
3. no radiographic signs of internal or external resorption, widened periodontal ligament space, or furcal/periapical radiolucency
4. physiological root resorption of no more than one third the root length
5. a deep caries lesion with a likelihood of pulp exposure during caries removal

Exclusion Criteria

* patients used any anti-inflammatory medication
Minimum Eligible Age

5 Years

Maximum Eligible Age

7 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Samah Mohsin

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cairo university

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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CEBD-CU-2018-10-31

Identifier Type: -

Identifier Source: org_study_id

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