Cytokines as Diagnostic Markers of Pulpal Inflammation and Their Impact on the Outcome of Vital Pulp Therapy
NCT ID: NCT07261761
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2022-10-01
2025-04-02
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Molars or premolars with Reversible or irreversible pulpits
fifteen patients with carious teeth showing signs and symptoms of pulp inflammation
Vital pulp therapy
1. Full medical and dental history will be taken from each patient.
2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth.
3. After anesthesia, Rubber dam is applied and complete caries removal will be done, deeply inside the cavity, the excavation will be done using low speed hand piece and excavator.
4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test.
5. After exposure, the pulp will be amputated to the level of the canal orifices (full pulpotomy) pulp vitality was confirmed by the presence of bleeding pulp tissue from all canals.
6. Putty MTA will gently place over the pulp.
7. The cavity will be sealed with initial deep layer of resin modified glass ionomer restoration (RMGI) and final superficial layer of composite restoration.
blood sample collection
after access opening blood sample will be collected
Caries free molars or premolars
fifteen patients with intact human premolars planed for extraction for orthodontic reason
Extraction
1. Full medical and dental history will be taken from each patient.
2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth.
3. After anesthesia, Rubber dam is applied.
4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test.
5. Extraction for orthodontic reasons.
blood sample collection
after access opening blood sample will be collected
Interventions
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Vital pulp therapy
1. Full medical and dental history will be taken from each patient.
2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth.
3. After anesthesia, Rubber dam is applied and complete caries removal will be done, deeply inside the cavity, the excavation will be done using low speed hand piece and excavator.
4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test.
5. After exposure, the pulp will be amputated to the level of the canal orifices (full pulpotomy) pulp vitality was confirmed by the presence of bleeding pulp tissue from all canals.
6. Putty MTA will gently place over the pulp.
7. The cavity will be sealed with initial deep layer of resin modified glass ionomer restoration (RMGI) and final superficial layer of composite restoration.
Extraction
1. Full medical and dental history will be taken from each patient.
2. Clinical and radiographic examination (Cone beam computed tomography) for the offending tooth.
3. After anesthesia, Rubber dam is applied.
4. A blood sample will be taken from the bleeding pulp tissue on a cotton pellet for Molecular test.
5. Extraction for orthodontic reasons.
blood sample collection
after access opening blood sample will be collected
Eligibility Criteria
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Inclusion Criteria
* Tooth should be vital on cold testing.
* Vital permanent premolar and molar on cold testing, with deep caries, subsequent pulp exposure and bleeding pulp tissue in all canals after complete pulpotomy.
* Diagnosis is either reversible or irreversible pulpitis with/ without periapical rarefaction.
* The tooth is restorable and free from advanced periodontal disease.
* Soft tissues around the tooth are normal with no swelling or sinus tract.
Exclusion Criteria
* Patients with clinical symptoms of periradicular inflammation or any periradicular radiographic lesions.
* Negative results for cold and electrical pulp testing
16 Years
45 Years
ALL
No
Sponsors
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Mansoura University
OTHER
Responsible Party
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Mohamed Khalifa
Researcher at faculty of dentistry Mansoura University
Locations
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Faculty of Dentistry, Mansoura Univeristy
Al Mansurah, , Egypt
Countries
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Other Identifiers
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M05060722
Identifier Type: -
Identifier Source: org_study_id
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