Endodontic Treatment Using CTZ Paste in Primary Teeth

NCT ID: NCT03731975

Last Updated: 2018-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-01

Study Completion Date

2019-12-01

Brief Summary

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The aim of this study is to evaluate the efficacy of CTZ Paste in primary teeth, compared to endodontic treatment with Guedes-Pinto Paste. This is a multicenter, randomized, double-blind (patient), controlled and non-inferiority clinical study on 174 primary molars and 174 primary incisors of 3-6 years-old children with carious lesions with pulp involvement. The sample unit will be the tooth, which will be randomized into two groups. The teeth allocated to the experimental group will be treated with CTZ Paste, whereas the treatment of those teeth allocated to the control group will employ the Guedes-Pinto Paste. The procedures performed will be evaluated clinically and radiographically at 6 and 12 months. Secondary outcomes such as cost, discomfort, satisfaction and quality of life will also be evaluated.

Detailed Description

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Conditions

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Pulpectomy Agents

Keywords

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Tooth, deciduous Pulp Capping and Pulpectomy Agents Pulpectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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CTZ Paste

Endodontic treatment with CTZ paste.

Group Type ACTIVE_COMPARATOR

CTZ Paste

Intervention Type PROCEDURE

Tooth allocated to this group will be treated with CTZ paste, according to the Cappielo's protocol (1964), updated by Moura et al. (2016).

GP Paste

Endodontic treatment with Guedes-Pinto paste.

Group Type EXPERIMENTAL

GP Paste

Intervention Type PROCEDURE

Tooth allocated to this group will be treated with Guedes-Pinto paste, according to the Guedes-Pinto's protocol (1981), updated by Mello-Moura et al. (2011).

Interventions

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CTZ Paste

Tooth allocated to this group will be treated with CTZ paste, according to the Cappielo's protocol (1964), updated by Moura et al. (2016).

Intervention Type PROCEDURE

GP Paste

Tooth allocated to this group will be treated with Guedes-Pinto paste, according to the Guedes-Pinto's protocol (1981), updated by Mello-Moura et al. (2011).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* children aged from 3 to 6 years and 11 months;
* children present at least one upper or lower molar or primary upper incisor with untreated carious lesion with pulp envelopment;
* children assent to participate in the study through collaborative behavior;
* children's parents/guardians consent to their participation by signing the Informed Consent Form (ICF).

Exclusion Criteria

* tooth with carious lesion involving three or more dental surfaces, making the restoration extremely difficult or impossible;
* tooth with internal or external resorption in more than 1/3 of the root length;
* tooth whose crypt of the successor permanent is affected;
* tooth which have less than 2/3 of the root;
* patients who present health problems with oral impairment.
Minimum Eligible Age

3 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Faculty Sao Leopoldo Mandic Campinas

OTHER

Sponsor Role lead

Responsible Party

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Jose Carlos P Imparato

Principal Investigator, Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculdade Sao Leopoldo Mandic

Campinas, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Jose Imparato, Dr

Role: CONTACT

Phone: +551130851046

Email: [email protected]

Facility Contacts

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Jose P Imparato, PhD

Role: primary

References

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Cappiello J. Tratamientos pulpares en incisivos primários. Rev Circ Od Ros 1964;52(4):133-45.

Reference Type BACKGROUND

de Deus Moura Lde F, de Lima Mde D, Lima CC, Machado JI, de Moura MS, de Carvalho PV. Endodontic Treatment of Primary Molars with Antibiotic Paste: A Report of 38 Cases. J Clin Pediatr Dent. 2016;40(3):175-7. doi: 10.17796/1053-4628-40.3.175.

Reference Type BACKGROUND
PMID: 27472562 (View on PubMed)

Furtado GE, Sousa ML, Barbosa TS, Wada RS, Martinez-Mier EA, Almeida ME. [Perceptions of dental fluorosis and evaluation of agreement between parents and children: validation of a questionnaire]. Cad Saude Publica. 2012 Aug;28(8):1493-505. doi: 10.1590/s0102-311x2012000800008. Portuguese.

Reference Type BACKGROUND
PMID: 22892969 (View on PubMed)

Guedes-Pinto AC, De Paiva JG, Bozzola JR. [Endodontic treatment of deciduous teeth with pulp necrosis]. Rev Assoc Paul Cir Dent. 1981 May-Jun;35(3):240-4. No abstract available. Portuguese.

Reference Type BACKGROUND
PMID: 6943625 (View on PubMed)

Mello-Moura AC, Fanaro J, Nicoletti MA, Mendes FM, Wanderley MT, Guedes-Pinto AC. Variability in the proportion of components of iodoform-based Guedes-Pinto paste mixed by dental students and pediatric dentists. Indian J Dent Res. 2011 Nov-Dec;22(6):781-5. doi: 10.4103/0970-9290.94668.

Reference Type BACKGROUND
PMID: 22484870 (View on PubMed)

Monse B, Heinrich-Weltzien R, Benzian H, Holmgren C, van Palenstein Helderman W. PUFA--an index of clinical consequences of untreated dental caries. Community Dent Oral Epidemiol. 2010 Feb;38(1):77-82. doi: 10.1111/j.1600-0528.2009.00514.x. Epub 2009 Dec 7.

Reference Type BACKGROUND
PMID: 20002630 (View on PubMed)

Wong DL, Baker CM. Smiling faces as anchor for pain intensity scales. Pain. 2001 Jan;89(2-3):295-300. doi: 10.1016/s0304-3959(00)00375-4. No abstract available.

Reference Type BACKGROUND
PMID: 11291631 (View on PubMed)

Other Identifiers

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SLM4

Identifier Type: -

Identifier Source: org_study_id