Itopride in Feeding Intolerance of Critically-ill Patients Receiving Enteral Nutrition
NCT ID: NCT03698292
Last Updated: 2018-10-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2018-10-31
2019-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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First group
Metoclopramide 10 mg tablets will be taken by the patients of this group three times daily for 7 days
Metoclopramide 10mg
Prokinetic Drug
Second Group
Itopride 50 mg tablets will be taken by the patients of this group three times daily for 7 days
Itopride
Prokinetic Drug
Interventions
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Itopride
Prokinetic Drug
Metoclopramide 10mg
Prokinetic Drug
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Age less than 18 years or more than 60 years.
* Previous upper gastrointestinal tract surgery, obstruction, hemorrhage or history of GI disease.
* Clinically significant hepatic dysfunction. (\>3 times above the upper end of normal range of bilirubin, γ-glutamyl transferase, aspartate transaminase, or lactate dehydrogenase)
* Regular use of H2 blockers, prokinetic, proton pump inhibitor or anticholinergic agents for previous 4 weeks.
* Patients with arrhythmia or atrioventricular blocks.
* Any condition or comorbid disease that might interfere with gastric emptying such as diabetes.
* Patients with head injuries.
18 Years
60 Years
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Eman Mohamed El Mokadem
Assistant Lecturer
Locations
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Kasr Al Ainy Hospital
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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References
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Gholipour Baradari A, Alipour A, Firouzian A, Moarab L, Emami Zeydi A. A Double-Blind Randomized Clinical Trial Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated ICU Patients. Acta Inform Med. 2016 Dec;24(6):385-389. doi: 10.5455/aim.2016.24.385-389.
Gomes PC, Caporossi C, Aguilar-Nascimento JE, Silva AM, Araujo VM. Residual gastric volume evaluation with ultrasonography after ingestion of carbohydrate- or carbohydrate plus glutamine-enriched beverages: a randomized, crossover clinical trial with healthy volunteers. Arq Gastroenterol. 2017 Jan-Mar;54(1):33-36. doi: 10.1590/S0004-2803.2017v54n1-06.
Elmokadem EM, El Borolossy RM, Bassiouny AM, Hanna MG, Darweesh EAG, Sabri NA. The efficacy and safety of itopride in feeding intolerance of critically ill patients receiving enteral nutrition: a randomized, double-blind study. BMC Gastroenterol. 2021 Mar 19;21(1):126. doi: 10.1186/s12876-021-01712-w.
Other Identifiers
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67
Identifier Type: -
Identifier Source: org_study_id
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