A Study to Evaluate Leuprolide Acetate 45 mg 6-Month Formulation in Children With Central Precocious Puberty (CPP)

NCT ID: NCT03695237

Last Updated: 2024-05-29

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-24

Study Completion Date

2023-11-29

Brief Summary

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The primary objective of the study is to assess the safety and efficacy of a leuprolide acetate (LA) 45 mg 6-month depot formulation for the treatment of CPP in children who are either naïve to treatment with a gonadotropin-releasing hormone agonist (GnRHa) or who have been previously treated with a GnRHa.

Detailed Description

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Conditions

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Central Precocious Puberty (CPP)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Leuprolide Acetate (LA)

Participants received leuprolide acetate (LA) 45 mg every 6 months administered as an intramuscular injection for up to 144 weeks.

Group Type EXPERIMENTAL

Leuprolide Acetate (LA)

Intervention Type DRUG

Administered intramuscularly as an injection

Interventions

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Leuprolide Acetate (LA)

Administered intramuscularly as an injection

Intervention Type DRUG

Other Intervention Names

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Lupron Depot

Eligibility Criteria

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Inclusion Criteria

* Children with CPP who are naïve to treatment with a gonadotropin-releasing hormone agonist (GnRHa) (females 2 - 8 years of age, or males 2 - 9 years of age) or who have been on standard GnRHa therapy for at least 6 months (females 2 - 10 years of age, or males 2 - 11 years of age).
* No history of clinically significant medical conditions or any other reason that the investigator determines would make the participant an unsuitable candidate to receive study drug.
Minimum Eligible Age

2 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Pediatric Endocrinology Associates /ID# 200629

Long Beach, California, United States

Site Status

Rady Children's Hospital San Diego /ID# 202491

San Diego, California, United States

Site Status

Children's Hospital Colorado /ID# 201645

Aurora, Colorado, United States

Site Status

Pediatric Endocrine Associates /ID# 201089

Greenwood Village, Colorado, United States

Site Status

Nemours Children's Health System /ID# 201331

Jacksonville, Florida, United States

Site Status

Arnold Palmer Hospital /ID# 201624

Orlando, Florida, United States

Site Status

Van Meter Pediatric Endocrinology /ID# 201688

Atlanta, Georgia, United States

Site Status

Rocky Mountain Diabetes and Osteoporosis Center /ID# 209878

Idaho Falls, Idaho, United States

Site Status

Indiana University /ID# 200526

Indianapolis, Indiana, United States

Site Status

Pediatric Endocrine Associates /ID# 202396

Boston, Massachusetts, United States

Site Status

University of Minnesota /ID# 200508

Minneapolis, Minnesota, United States

Site Status

Children's Mercy Hospital/ID# 200221

Kansas City, Missouri, United States

Site Status

University of Oklahoma /ID# 200659

Tulsa, Oklahoma, United States

Site Status

Penn State Hershey Medical Ctr /ID# 200287

Hershey, Pennsylvania, United States

Site Status

Children's Hospital of Philadelphia - Main /ID# 203846

Philadelphia, Pennsylvania, United States

Site Status

Cook Children's Med. Center /ID# 212937

Fort Worth, Texas, United States

Site Status

Multicare Institute for Research and Innovation /ID# 202188

Tacoma, Washington, United States

Site Status

Pediatric Endocrine Research Associates /ID# 200131

San Juan, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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M16-904

Identifier Type: -

Identifier Source: org_study_id

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