Fracture Gap After Herbert Screw Insertion by 3d Stents Vs Titanium Plate(Minimally Displaced Mandibular Angle Fracture)

NCT ID: NCT03692260

Last Updated: 2018-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-25

Study Completion Date

2019-07-01

Brief Summary

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interfragmentary gap measurement using Herbert cannulated headless screw using a 3D surgical customized template versus titanuim plate

Detailed Description

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* Intervention for each group

1. Diagnosis

* for group I and II According to inclusion and exclusion criteria, patients are selected after a comprehensive clinical and radiographic examination and understanding of participant s chief complains.
* Inspection for the soft tissue laceration, edema, ecchymosis, hemorrhage, cerebrospinal fluid leakage, gingival lacerations, mandible contour deformity, facial asymmetry and the other facial bones bilateral palpation starting from the condylar region descending towards the posterior border of the mandible to look for any tenderness, step deformities or crepitus. Examination of the integrity of the neurosensory and motor function of the injured area.
* Checking the amount of occlusal discrepancy with complete and comprehensive examination of the dentition.
* Mandibular movements will also be checked with emphasis on maximal Interincisal opening and midline shift in opening and closing positions.
2. Surgical planning Group I :participants will be treated using Herbert headless cannulated screw(Zimmer® Herbert™ ,united states of America )Cannulated Bone Screw) using 3d template GroupII :patients are treated using titanium plates (4 or 6 holes according to each case) orthomed ,6th of October,Egypt)
3. Intra-operative procedures:

-All of the participants will be treated under general anaesthesia using nasal intubation
* The occlusion was secured with temporary IMF and the fracture line was exposed and manually reduced.
* Infiltration Local anesthesia with vasoconstrictor will be injected intraorally at the incision site for hemostatic purposes and pain control.
* Scrubbing and draping of the patient will be carried out in a standard fashion.
* An intraoral incision to expose the fracture line. Dissection and reflection to reach the bone For the intervention group planning using the ct software to produce a guiding template of the mandible in the normal position for the insertion of the Herbert screw.

Reduction of the fracture -Fixation of the fractured segments through Herbert screw using the 3D template fabricated by Plastycad 3diemme Italy(group I), or by using titanium the plate (groupII)

-Double checking and verification of the occlusion before wound closure.

-Wounds are debrided and sutured.
4. Postoperative

\- Cold application at the site of surgery in the form of ice packs 10 minutes every hour in the first 6 hours.

-Broad spectrum antibiotic therapy in the form of Unasyn 1500 mg vials was given as an IV shot to the patient every 12 hours for 5 days to reduce the risk of infection. (Unasyn®: manufactured by Pfizer, Egypt S.A.E Cairo, A.R.E)
* Non-steroidal anti-inflammatory drug will be administered in the form of Voltaren 75mg ampoule 3 times daily for 3 days to relief the pain. (Voltaren®: NOVARTIS PHARMA S.A.E. Cairo, under license from: Novartis Pharma AG, Basle, Switzerland.)
5. Follow up \& Evaluation

Clinical follow up parameters:

For group I and group II - Dehiscence of the soft tissue and hardware exposure. - Pain over visual analogue scale over first 72 hours.
* Maximum incisal opening (MIO)
* Stability of the fractured segments.

Radiographic follow up parameters:

\- Bone union/nonunion and malunion (OPG).
* Bone to bone contact via mandible form \& border contour (OPG) (3diagnosys 3diemme Italy version 4.2 Any participant that can cause an adverse effect to the intervention/control group will be excluded
* the patients will receive their panoramic x-ray at the accurate indicated intervals.

The the MIO will be tested for all patients under the same chair postion using the same caliper, the visual analogue scale to measure the pain will be explained to the patient to prevent any misunderstanding and for the sensory function the patients will be asked to close their eyes before we start to prevent any misleading data as he will not be able to see area we are checking. Those Strategies will be used to improve adherence to intervention protocols.

Conditions

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Minimally Displaced Mandibular Angle Fracture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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intervention group

3D stent in Herbert screw insertion vs titanium plate

Group Type ACTIVE_COMPARATOR

3D stent in Herbert screw insertion vs titanium plate

Intervention Type PROCEDURE

benefit of 3d template in fracture gap

control group

titanium plate

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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3D stent in Herbert screw insertion vs titanium plate

benefit of 3d template in fracture gap

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patient age between 20 to 45

* Patients with minimally displaced angular fracture
* Patients free from any systemic disease that delay bone healing
* Patients free from any metabolic bone disease delaying the healing
* Patients who approved to be included in the trial and signed the informed consent.

Exclusion Criteria

* .Patients receiving chemotherapy or radiotherapy "due to the risk of low bone quality and healing.(Hopewell, 2003)

* Patients who refused to be included in the trial
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Nevine Alaa Eldine

assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hussein h Abd elrahman, a professor

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Central Contacts

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Nevine AE Fathy mohammed elfath omar, a lecturer

Role: CONTACT

01011180702 ext. 202

omnia i sultan, lecturer

Role: CONTACT

01001741757 ext. 202

Other Identifiers

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CEBD-CU-2018-09-29

Identifier Type: -

Identifier Source: org_study_id

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