Combining Mechanisms for Better Outcomes (COMBO)

NCT ID: NCT03689920

Last Updated: 2022-01-11

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-03

Study Completion Date

2021-12-15

Brief Summary

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To evaluate the effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities as compared to conventional SCS in patients with chronic pain when using the Boston Scientific Spectra WaveWriter SCS System.

Detailed Description

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To evaluate the effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities as compared to conventional SCS in patients with chronic pain when using the Boston Scientific Spectra WaveWriter SCS System.

Conditions

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Chronic Pain Back Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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WaveWriter Settings

WaveWriter Programming

Group Type ACTIVE_COMPARATOR

Boston Scientific Spectra WaveWriter™ Spinal Cord Stimulation (SCS) System

Intervention Type DEVICE

The Spectra WaveWriter Spinal Cord Stimulator (SCS) System is indicated as an aid in the management of chronic intractable pain of the trunk and/or limbs, including unilateral or bilateral pain associated with the following: failed back surgery syndrome, Complex Regional Pain Syndrome (CRPS) Types I and II, intractable low back pain and leg pain.

Conventional Settings

Conventional Programming

Group Type ACTIVE_COMPARATOR

Boston Scientific Spectra WaveWriter™ Spinal Cord Stimulation (SCS) System

Intervention Type DEVICE

The Spectra WaveWriter Spinal Cord Stimulator (SCS) System is indicated as an aid in the management of chronic intractable pain of the trunk and/or limbs, including unilateral or bilateral pain associated with the following: failed back surgery syndrome, Complex Regional Pain Syndrome (CRPS) Types I and II, intractable low back pain and leg pain.

Interventions

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Boston Scientific Spectra WaveWriter™ Spinal Cord Stimulation (SCS) System

The Spectra WaveWriter Spinal Cord Stimulator (SCS) System is indicated as an aid in the management of chronic intractable pain of the trunk and/or limbs, including unilateral or bilateral pain associated with the following: failed back surgery syndrome, Complex Regional Pain Syndrome (CRPS) Types I and II, intractable low back pain and leg pain.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Chronic pain of the trunk and/or limbs for at least 6 months with back pain greater or equal to leg pain.
* 22 years of age or older at time of enrollment
* Able to independently read and complete all questionnaires and assessments provided in English
* Signed a valid, IRB-approved informed consent form (ICF) provided in English

Exclusion Criteria

* Any pain-related diagnosis or medical/psychological condition that, in the clinician's best judgment, might confound reporting of study outcomes
* Significant cognitive impairment that, in the opinion of the Investigator, would reasonably be expected to impair the study candidate's ability to participate in the study
* Breast-feeding or planning to get pregnant during the course of the study or not using adequate contraception
* Participating, or intends to participate, in another clinical trial that may influence the data that will be collected for this study
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mark Wallace, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of California, San Diego

Locations

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Center for Pain and Supportive Care

Phoenix, Arizona, United States

Site Status

UCSD Medical Center - Jacobs Medical Center

La Jolla, California, United States

Site Status

Denver Back Pain Specialists

Greenwood Village, Colorado, United States

Site Status

South Lake Pain Institute, Inc

Clermont, Florida, United States

Site Status

Willis-Knighton River Cities Clinical Research Center

Shreveport, Louisiana, United States

Site Status

Michigan Pain Consultants

Grand Rapids, Michigan, United States

Site Status

Forest Health Medical Center

Ypsilanti, Michigan, United States

Site Status

KC Pain Centers

Lee's Summit, Missouri, United States

Site Status

Carolinas Research Institute, LLC

Huntersville, North Carolina, United States

Site Status

The Center for Clinical Research, LLC

Winston-Salem, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Toledo Clinic

Toledo, Ohio, United States

Site Status

Pacific Sports and Spine, LLC

Eugene, Oregon, United States

Site Status

Precision Spine Care

Tyler, Texas, United States

Site Status

EvergreenHealth Pain Care

Kirkland, Washington, United States

Site Status

Countries

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United States

References

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Wallace MS, North JM, Phillips GM, Calodney AK, Scowcroft JA, Popat-Lewis BU, Lee JM, Washabaugh EP 3rd, Paez J, Bolash RB, Noles J, Atallah J, Shah B, Ahadian FM, Trainor DM, Chen L, Jain R. Combination therapy with simultaneous delivery of spinal cord stimulation modalities: COMBO randomized controlled trial. Pain Manag. 2023 Mar;13(3):171-184. doi: 10.2217/pmt-2022-0101. Epub 2023 Mar 3.

Reference Type DERIVED
PMID: 36866658 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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A4070

Identifier Type: -

Identifier Source: org_study_id

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