Mutual Interactions Between Absence Epilepsy Seizures and the Integration of Sensory Stimuli

NCT ID: NCT03676543

Last Updated: 2022-09-21

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 1 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-06-07
• Study Completion Date: 2022-08-29

Brief Summary

Epileptic seizures arise from neuronal defects that often alter the capacity of the brain to process sensory information. During absence seizures, a frequent epileptic syndrome in children, the normal conscious and perceptual processes are temporarily interrupted. This is the result of abnormal synchronized neural activities in the thalamo-cortical loops, leading to bilateral spike-and-wave discharges (SWDs) in the cortical electroencephalograms (EEGs). The brain mechanisms underlying the lack of sensory experience during absence seizures are disputed. Based on preliminary data, the investigators hypothesize that the alternation of 'spike' and 'wave' patterns during seizure could cause a time-to-time inconstancy in cortical responsiveness, preventing conscious perception. Using a real-time closed-loop stimulation system, the investigators will research how the S- and W-patterns specifically alter the sensory-evoked responses in the EEG. During a standard EEG, visual stimulations will be applied between and during absence seizures to test the hypothesis that repeated sensory stimuli, applied with an appropriate timing relative to the seizure-related oscillatory cycle, could negatively interfere with the regenerative network mechanisms involved in the occurrence of SWDs. The completion of this project should permit to unveil a new neuronal mechanism supporting the lack of conscious experience during absences and pave the way for new clinical non-invasive strategies to interrupt ongoing seizure activity.

Conditions

Childhood or Juvenile Absence Epilepsy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Timed repetitive sensory stimulation

Timed repetitive sensory stimulation (TRSS) will be applied at the onset or during seizures

Group Type: EXPERIMENTAL

Timed repetitive sensory stimulation

Intervention Type: PROCEDURE

Timed repetitive sensory stimulation (TRSS) will be applied at the onset or during seizures

Interventions

Timed repetitive sensory stimulation

Timed repetitive sensory stimulation (TRSS) will be applied at the onset or during seizures

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age 2-20 years
• childhood or juvenile absence epilepsy defined by International Ligue Against Epilepsy (ILAE)
• Electroencephalogram (EEG) indicated for clinical follow-up

• Visual deficit
• Abnormal Magnetic Resonance Imaging (MRI)
• Medical history of photosensitive epileptic seizures

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 21 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Fondation OPH A. de Rothschild

Paris, , France

Countries

France

Other Identifiers

MCX_2017_28

Identifier Type: -

Identifier Source: org_study_id