Platelet-Rich Plasma in Acute Muscle Injuries

NCT ID: NCT03676205

Last Updated: 2020-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-03

Study Completion Date

2020-01-08

Brief Summary

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OBJECTIVE: To evaluate the effect of Platelet Rich Plasma (PRP) injection in muscle injuries. The investigators check football players in the acute phase of hamstrings or quadriceps injuries.

Efficacy and safety are evaluated. There are two intramuscular infiltration of PRP (Ortho pras ® system) or a homeopathic product (Traumeel ®) in each of the football players. The number of days between the date of injury and the return to play, the pain, the recurrence and the adverse reactions are registered.

Detailed Description

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STUDY DESIGN: Randomized Clinical Trial.

METHODS:

41 football players are included in the study. It is used randomly PRP injection or a homeopathic product in muscle injuries (hamstring), in the early stage (first 48-72 hours).

One week later, the investigators do a second infiltration with the same product, always ultrasound guided. 3-4 weeks after the injury, different variables are evaluated: the injurie with ultrasounds , self-perception test, muscle strength, flexibility, jump and run. It is compared the elapsed time in days in each of the groups: RETURN TO PLAY.

Furthermore, the PAIN, RECURRENCE RATE and ADVERSE REACTIONS are evaluated.

Conditions

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Muscle Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Two homogeneus groups with 1:1 possibilities to receive PRP or a homeopathic product.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
The patient doesn't know the treatment. The person who analyze the data (outcomes assessor) doesn't know the treatment.

Study Groups

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Platelet-Rich Plasma

24-72 hours after having a muscular lesion, the doctor injects an intramuscular ecoguided infiltration of 6-7 ml of PRP .

After 4-5 days from the injury the patient starts physiotherapy adapted by stages, according to the muscular group affected.

After 7 days from the first infiltration, the patient will recived the second infiltration of 6-7 ml of PRP.

Group Type EXPERIMENTAL

PRP

Intervention Type BIOLOGICAL

Platelet-Rich Plasma

Traumel ®

24-72 hours after having a muscular lesion, the doctor injects an intramuscular ecoguided infiltration of 4 ml of a homeopathic product (Traumeel ®) After 4-5 days from the date of injury, the patient starts physiotherapy adapted by stages, according to the muscular group affected.

After 7 days from the first infiltration, the patient will receive the second infiltration of 4 ml of a homeopathic product.

Group Type OTHER

Traumeel

Intervention Type OTHER

Homeophatic Treatment

Interventions

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PRP

Platelet-Rich Plasma

Intervention Type BIOLOGICAL

Traumeel

Homeophatic Treatment

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Over 18 years old.
* Acute muscular Injury Type 3a-3b (Múnich classification) in hamstring muscles
* Informed consent signed

Exclusion Criteria

* Hamstring injury (last 6 months).
* Previous infiltration in hamstring.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of the Basque Country (UPV/EHU)

OTHER

Sponsor Role lead

Responsible Party

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Javier González Iglesias

Medical Doctor (orthopedic surgeon)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Javier Gonzalez Iglesias, Dr

Role: PRINCIPAL_INVESTIGATOR

Basque Health System - Osakidetza

Locations

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Javier Gonzalez Iglesias

Bilbao, Bizkaia, Spain

Site Status

Countries

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Spain

References

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Gonzalez-Iglesias J. [Therapeutic potential of platelet rich plasma. Reflections on its research and development]. Rev Esp Cir Ortop Traumatol. 2013 Jul-Aug;57(4):237-9. doi: 10.1016/j.recot.2013.04.001. Epub 2013 May 28. No abstract available. Spanish.

Reference Type RESULT
PMID: 23885648 (View on PubMed)

Other Identifiers

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PRP-MUSCULO-2014-2019

Identifier Type: -

Identifier Source: org_study_id

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