Time Course of Circulating Myocardial Biomarkers After a TASH Procedure.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-10

Study Completion Date

2021-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study evaluates the released myocardial substances in blood of HOCM patients after TASH procedure (small "controlled" myocardial infarction). This helps to identify new pathomechanisms and biomarker and thus provides a better understanding of development and progress of cardiac insufficiency.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance

NCT04773652

ST Elevation Myocardial Infarction Remodeling, Left Ventricle

COMPLETED

Biomarkers in Acute Cardiac Care

NCT02355457

Acute Coronary Syndrome Myocardial Infarction Chest Pain

RECRUITING

Coronary Artery Disease (CAD) in Postmenopausal Women

NCT00763464

Postmenopausal Women Stable Angina Pectoris

COMPLETED NA

Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

NCT05261256

Cardiovascular Diseases Pediatric Cancer

ENROLLING_BY_INVITATION

High-sensitivity Troponin in Cardiac Surgery

NCT01913873

Heart; Dysfunction Postoperative, Cardiac Surgery Myocardial Infarction Myocardial Injury

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

All patients who receive a TASH procedure in the Medical Clinic I routinely receive routinely implementation of arterial pressure catheter for invasive blood pressure monitoring (usually Arteria radialis) as well as a central venous catheter. Directly after the procedure, the blood is taken through the central venous catheter. The operation is then terminated as planned.

The postoperative treatment is performed according to the Standard Operating Procedures (SOPs) of the Medical clinic I -regular blood sampling is performed to monitor the patient's cardiac, renal and hepatic lab values. The patient is released on the 3-5th post-operative day.

As part of a routine outpatient visit to the Medical Clinic I 1 week and 1 month after the TASH procedure, an anamnestic record as well as a blood analysis is made. One month after the TASH procedure, an echocardiographic follow-up of the HOCM is routinely performed.

Adverse events or serious adverse events are documented, assessed and reported in accordance with GCP (good clinical practice).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac Insufficiency

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

HOCM patients

selected for routine TASH procedure

blood withdrawal

Intervention Type OTHER

* peripheral-venous before TASH, day 1, 2, 3, one week and one month after TASH procedure
* central-venous during TASH

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood withdrawal

* peripheral-venous before TASH, day 1, 2, 3, one week and one month after TASH procedure
* central-venous during TASH

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* a clinical indication for TASH procedure
* an access to blood vessels
* a person qualified for legal acts, mentally abte to follow the instructions of study stuff

Exclusion Criteria

* patients with severe anaemia - Hb \<8 mg/dL
* patients with acute infectious diseases (e.g. pneumonia)
* patients with acute myocardial ischaemia (e.g. angina pectoris or ECG alterations under strain)
* patients with acute coronary syndrome in the last three months
* patients that were hospitalized for Acute Heart Failure during the last month and had to be treated by diuretics or inotropes
* a pregnant and/or breastfeeding women
* Persons that are located by a court or administrative decision in an Institution
* Persons with a relationship of dependency to investigator
* Persons with simultaneous participation in another clinical trial
* administration of an investigational drug 30 days before start of the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No