Assessing the Effectiveness of Psychiatric Interventions on the Inpatient Unit
NCT ID: NCT03626142
Last Updated: 2022-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
200 participants
OBSERVATIONAL
2018-07-09
2025-12-01
Brief Summary
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Detailed Description
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Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF) will be collected at one month post-intervention.
If the participant has a psychiatric diagnosis(/es) other than MDD, questionnaires measuring the symptoms associated with the participant's other psychiatric diagnosis/(es) will also be administered.
Follow-up assessments from 10-24 weeks will include:
MADRS SSI BDI-II C-SSRS self-report short version
If the participant has a psychiatric diagnosis other than MDD, questionnaires measuring the symptoms associated with the participant's other psychiatric diagnosis/(es) will also be administered.
The questionnaires that will be used to assess symptoms associated with primary psychiatric diagnoses are:
* Bipolar disorder: YMRS
* Schizoaffective disorder/ Schizophrenia/Schizophreniform disorder: positive and negative symptom scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS)
* Alcohol use disorder: Alcohol craving questionnaire self-report (ACQ-SR) and obsessive compulsive drinking scale (OCDS)
* Drug use disorders: Modified versions of the alcohol scales to make these relevant to the particular drug of abuse.
* Anorexia Nervosa: Yale-Brown-Cornell Eating Disorder Scale \[YBC-EDS\], Eating disorder examination questionnaire (EDE-Q)
* Bulimia Nervosa: Yale-Brown-Cornell Eating Disorder Scale \[YBC-EDS\], Eating disorder examination questionnaire (EDE-Q)
* Binge eating disorder: Young-Brown Obsessive Compulsive Scale Modified for Binge Eating \[YBOCS-BE\]
* OCD: Obsessive compulsive inventory (OCI) and Yale-Brown Obsessive Compulsive Scale (YBOCS)
* PTSD: Post-traumatic Stress Disorder Checklist-Civilian Version \[PCL-C\]
* Generalized anxiety disorder: Generalized Anxiety Disorder 7-item (GAD-7) scale
* Chronic pain: Numeric Rating Scale (NRS) for Chronic Pain
* Panic Disorder: Panic Disorder Severity Scale (PDSS)
* Somatoform Disorders: The Somatic Symptom Scale (SSS-8)
* Impulse Control disorders: Massachusetts General Hospital Hairpulling Scale (This questionnaire will be adapted depending on the urges the patient cannot control e.g. compulsive picking) BPD: The Borderline Evaluation of Severity Over Time (BEST)
At all time points, information regarding medication changes and other psychiatric treatments will be collected.
Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Study Groups
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Left DLPFC aTBS stimulation
Patients who have received accelerated theta burst stimulation delivered to the left dorsolateral prefrontal cortex on the inpatient unit at Stanford
No interventions assigned to this group
ACC aTBS stimulation
Patients who have received accelerated theta burst stimulation delivered to the anterior cingulate cortex on the inpatient unit at Stanford
No interventions assigned to this group
ECT
Patients who have received ECT on the inpatient unit at Stanford
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Stanford University
OTHER
Responsible Party
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Nolan R
Associate Professor, Psychiatrist, Neurologist
Principal Investigators
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Nolan Williams, MD
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Stanford Hospital
Palo Alto, California, United States
Countries
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References
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Kelly MS, Oliveira-Maia AJ, Bernstein M, Stern AP, Press DZ, Pascual-Leone A, Boes AD. Initial Response to Transcranial Magnetic Stimulation Treatment for Depression Predicts Subsequent Response. J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):179-182. doi: 10.1176/appi.neuropsych.16100181. Epub 2016 Nov 30.
Haq AU, Sitzmann AF, Goldman ML, Maixner DF, Mickey BJ. Response of depression to electroconvulsive therapy: a meta-analysis of clinical predictors. J Clin Psychiatry. 2015 Oct;76(10):1374-84. doi: 10.4088/JCP.14r09528.
Berggren A, Gustafson L, Hoglund P, Johanson A. A long-term follow-up of clinical response and regional cerebral blood flow changes in depressed patients treated with ECT. J Affect Disord. 2014;167:235-43. doi: 10.1016/j.jad.2014.06.005. Epub 2014 Jun 12.
Murrough JW, Perez AM, Pillemer S, Stern J, Parides MK, aan het Rot M, Collins KA, Mathew SJ, Charney DS, Iosifescu DV. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry. 2013 Aug 15;74(4):250-6. doi: 10.1016/j.biopsych.2012.06.022. Epub 2012 Jul 27.
Dell'osso B, D'Urso N, Castellano F, Ciabatti M, Altamura AC. Long-term efficacy after acute augmentative repetitive transcranial magnetic stimulation in bipolar depression: a 1-year follow-up study. J ECT. 2011 Jun;27(2):141-4. doi: 10.1097/YCT.0b013e3181f66601.
Other Identifiers
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45301
Identifier Type: -
Identifier Source: org_study_id
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