The Effect of Dexmedetomidine for Emergence Cough

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-16

Study Completion Date

2019-03-27

Brief Summary

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Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

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Detailed Description

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Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Conditions

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Cough

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Caregivers Investigators

Study Groups

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Dexmedetomidine

Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period

Group Type EXPERIMENTAL

Dexmedetomidine

Intervention Type DRUG

Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery

Remifentanil

Intervention Type DRUG

Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)

Remifentanil

Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period

Group Type ACTIVE_COMPARATOR

Remifentanil

Intervention Type DRUG

Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)

Normal saline

Intervention Type DRUG

Normal saline was infused over 10 min before end of the surgery

Interventions

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Dexmedetomidine

Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery

Intervention Type DRUG

Remifentanil

Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)

Intervention Type DRUG

Normal saline

Normal saline was infused over 10 min before end of the surgery

Intervention Type DRUG

Other Intervention Names

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Prededex Ultiva 0.9% NaCl

Eligibility Criteria

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Inclusion Criteria

* ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia

Exclusion Criteria

* predicted difficult airway
* body mass index \> 35 kg/m2,
* recent upper respiratory infection
* asthma
* current smoker
* patients using angiotensin converting enzyme-inhibitors
* uncontrolled hypertension

Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No