Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

NCT ID: NCT03621891

Last Updated: 2018-08-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-05-01
• Study Completion Date: 2017-05-01

Brief Summary

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

Detailed Description

Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.

Conditions

Chronic Periodontitis; Occlusal Trauma

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

healthy individuals

Orally and systemically healthy individuals who has no hypo-functional teeth, hyper-occlusion or occlusal trauma

No interventions assigned to this group

periodontitis patients

Systemically healthy individuals who has chronic periodontitis but no hypo-functional teeth, hyper-occlusion or occlusal trauma

No interventions assigned to this group

healthy-occlusal trauma

Orally and systemically healthy individuals who has occlusal trauma caused by bruxism

No interventions assigned to this group

periodontitis-occlusal trauma

Systemically healthy individuals who has both chronic periodontitis and occlusal trauma caused by bruxism

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Systemical health
• No drug use
• No pregnancy or lactation For group 3 and 4;
• Bruxism at least for 2 years
• Occlusal trauma
• Existence of at least 20 functioning teeth

Exclusion Criteria

• Smoking
• Pregnancy/lactation
• Systemical disease
• Drug use
• Absence of at least 20 functioning teeth

• Minimum Eligible Age: 29 Years
• Maximum Eligible Age: 42 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Tokat Gaziosmanpasa University

OTHER

Sponsor Role: lead

Responsible Party

Hatice Balci Yuce

Dr, principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

HATICE BALCI YUCE, PhD

Role: PRINCIPAL_INVESTIGATOR

Gaziosmanpasa University

Locations

Gaziosmanpasa University Faculty of Dentistry

Tokat Province, , Turkey (Türkiye)

Gaziosmanpasa University

Tokat Province, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

balciyuce84

Identifier Type: -

Identifier Source: org_study_id