Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
29 participants
INTERVENTIONAL
2013-09-30
2016-01-31
Brief Summary
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Detailed Description
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Subjects will be excluded if they have taken antibiotics within the previous three months, are pregnant, breast-feeding or allergic against penicillin.
The participants will be given a single dose of 2 g amoxicillin. Saliva samples will be collected before administration of antibiotics (day 1) and on day 2, 5, 10, 17 and 24. Un-stimulated saliva will be accumulated in a plastic container. Concentration of amoxicillin in saliva will be measured on day 1, 2 and 5. Samples will be used for the determination of antibiotic concentration. Analyses of the sensitivities to amoxicillin and some other clinically relevant antibiotic compounds will also be performed.
Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Amoxicillin
All subjects receive one dose of 2 g Amoxicillin
Amoxicillin
Amoxicillin
Interventions
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Amoxicillin
Amoxicillin
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Healthy
* Age 18-45
* Understands the study procedure and speaks Swedish and/or English
Exclusion Criteria
* Pregnant
* Breast-feeding
* Allergic against penicillin
* Concomitantly participate in another medical product study
* Treatment with any kind of medication, health food preparations or probiotics
18 Years
45 Years
ALL
Yes
Sponsors
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Bodil Lund
OTHER
Responsible Party
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Bodil Lund
Assoc. professor, Dentist
Principal Investigators
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Margareta Hultin, Dentist
Role: PRINCIPAL_INVESTIGATOR
Department of Dental Medicine, Karolinska Institute
Locations
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Karolinska University Hospital. Department of Dental Medicine
Stockholm, Huddinge, Sweden
Countries
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Other Identifiers
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2013-000405-23
Identifier Type: -
Identifier Source: org_study_id
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