A Study of Baricitinib (LY3009104) in Participants With Systemic Lupus Erythematosus

NCT ID: NCT03616912

Last Updated: 2023-01-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

830 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-02

Study Completion Date

2022-03-09

Brief Summary

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The reason for this study is to see how effective and safe the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE).

Detailed Description

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Conditions

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Systemic Lupus Erythematosus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Participants received two placebo tablets: one matching baricitinib 4 milligram (mg) and one matching baricitinib 2 mg administered orally every day (QD) for 52 weeks.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered orally.

2 mg Baricitinib

Participants received one Baricitinib 2 mg tablet and one placebo tablet matching Baricitinib 4 mg administered QD for 52 weeks.

Group Type EXPERIMENTAL

Baricitinib

Intervention Type DRUG

Administered orally.

Placebo

Intervention Type DRUG

Administered orally.

4 mg Baricitinib

Participants received one Baricitinib 4 mg tablet and one placebo tablet matching baricitinib 2 mg administered orally every day (QD) for 52 weeks.

Group Type EXPERIMENTAL

Baricitinib

Intervention Type DRUG

Administered orally.

Placebo

Intervention Type DRUG

Administered orally.

Placebo Maximum Extended Enrollment (MEE)

Participants received two placebo tablets: one matching baricitinib 4 mg and one matching baricitinib 2 mg administered orally QD for 52 weeks.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered orally.

2 mg Baricitinib (MEE)

Participants received one Baricitinib 2 mg tablet and 1 placebo tablet matching Baricitinib 4 mg administered QD for 52 weeks.

Group Type EXPERIMENTAL

Baricitinib

Intervention Type DRUG

Administered orally.

Placebo

Intervention Type DRUG

Administered orally.

4 mg Baricitinib (MEE)

Participants received one Baricitinib 4 mg tablet and one placebo tablet matching baricitinib 2 mg administered orally every day (QD) for 52 weeks.

Group Type EXPERIMENTAL

Baricitinib

Intervention Type DRUG

Administered orally.

Placebo

Intervention Type DRUG

Administered orally.

Interventions

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Baricitinib

Administered orally.

Intervention Type DRUG

Placebo

Administered orally.

Intervention Type DRUG

Other Intervention Names

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LY3009104

Eligibility Criteria

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Inclusion Criteria

* Have a clinical diagnosis of SLE at least 24 weeks prior to screening.
* Have documentation of having met at least 4 of 11 Revised Criteria for Classification of Systemic Lupus Erythematosus according to the 1997 Update of the 1982 American College of Rheumatology (ACR) criteria for classification of SLE prior to randomization.
* Have a positive antinuclear antibody (ANA) (titer ≥1:80) and/or a positive anti-double-stranded deoxyribonucleic acid (dsDNA), and/or a positive anti-Smith (anti-Sm) as assessed by a central laboratory during screening.
* Have a total Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score ≥6 during screening.
* Have a clinical SLEDAI-2K score ≥4 at randomization.
* Have at least 1 British Isles Lupus Assessment Group (BILAG) A score or 2 BILAG B scores during screening.
* Are receiving at least one of the following standard of care medications for SLE:

* A single antimalarial at a stable dose for at least 8 weeks prior to screening
* A single immunosuppressant at a stable dose for at least 8 weeks prior to screening
* An oral corticosteroid, initiated at least 4 weeks prior to screening, at a stable dose ≤40 milligrams/day prednisone (or equivalent) for at least 2 weeks prior to screening. If the participant is not receiving an antimalarial or immunosuppressant, the dose of corticosteroid must be ≥7.5 milligrams/day prednisone (or equivalent)

Exclusion Criteria

* Have severe active lupus nephritis.
* Have active central nervous system (CNS) lupus.
* Have a history or presence of cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, hematological, neurological, or neuropsychiatric disorders or any other serious and/or unstable illness that, in the opinion of the investigator, could constitute an unacceptable risk when taking investigational product or interfere with the interpretation of data.
* Have a current or recent clinically serious viral, bacterial, fungal, or parasitic infection.
* Have received cyclophosphamide (or any other cytotoxic agent) within 12 weeks prior to screening.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Incyte Corporation

INDUSTRY

Sponsor Role collaborator

Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Achieve Clinical Research, LLC

Birmingham, Alabama, United States

Site Status

University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Arizona Arthritis & Rheumatology Research, PLLC

Glendale, Arizona, United States

Site Status

University of Arizona

Tucson, Arizona, United States

Site Status

St. Joseph Heritage Medical Group

Fullerton, California, United States

Site Status

MD Medical Corporation

Hemet, California, United States

Site Status

ACRC Studies

Poway, California, United States

Site Status

Office: Hans R Barthel M.D.

Santa Barbara, California, United States

Site Status

Medvin Clinical Research - Weidmann

Whittier, California, United States

Site Status

Denver Arthritis Clinic - Lowry

Denver, Colorado, United States

Site Status

New England Research Associates

Bridgeport, Connecticut, United States

Site Status

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Arthritis and Rheumatic Disease

Aventura, Florida, United States

Site Status

Rheumatology Associates of South Florida

Boca Raton, Florida, United States

Site Status

Clinical Research of West Florida, Inc. (Clearwater)

Clearwater, Florida, United States

Site Status

Arthritis and Rheumatology Center of South Florida

Margate, Florida, United States

Site Status

Lakes Research, LLC

Miami Lakes, Florida, United States

Site Status

Millennium Research

Ormond Beach, Florida, United States

Site Status

IRIS Research and Development, LLC

Plantation, Florida, United States

Site Status

ForCare Clinical Research

Tampa, Florida, United States

Site Status

Piedmont Healthcare

Atlanta, Georgia, United States

Site Status

Atlanta Center for Clinical Research

Atlanta, Georgia, United States

Site Status

St Luke's Clinic - Intermountain Orthopaedics

Boise, Idaho, United States

Site Status

Rockford Orthopedic Associates

Rockford, Illinois, United States

Site Status

Henry Ford Health System

Detroit, Michigan, United States

Site Status

Clinical Research Institute of Michigan, LLC

Saint Clair Shores, Michigan, United States

Site Status

St. Louis Rheumatology

St Louis, Missouri, United States

Site Status

Glacier View Research Institute - Endocrinology

Kalispell, Montana, United States

Site Status

Allied Clinical Research

Reno, Nevada, United States

Site Status

Albuquerque Center for Rheumatology

Albuquerque, New Mexico, United States

Site Status

SUNY Health Science Center

Brooklyn, New York, United States

Site Status

St. Lawrence Health System

Canton, New York, United States

Site Status

Northwell Health

Great Neck, New York, United States

Site Status

The Feinstein Institute for Medical Research

Manhasset, New York, United States

Site Status

Columbia University Medical Center

New York, New York, United States

Site Status

Buffalo Rheumatology

Orchard Park, New York, United States

Site Status

Joint and Muscle Medical Care

Charlotte, North Carolina, United States

Site Status

Medication Management, LLC

Greensboro, North Carolina, United States

Site Status

PMG Research of Wilmington

Wilmington, North Carolina, United States

Site Status

Cincinnati Arthritis Associates

Cincinnati, Ohio, United States

Site Status

The Ohio State University

Columbus, Ohio, United States

Site Status

Paramount Medical Research

Middleburg Heights, Ohio, United States

Site Status

Arthritis & Rheumatology Center of Oklahoma PLLC

Oklahoma City, Oklahoma, United States

Site Status

East Penn Rheumatology Associates

Bethlehem, Pennsylvania, United States

Site Status

UPMC Lupus Center of Excellence

Pittsburgh, Pennsylvania, United States

Site Status

West Tennessee Research Institute

Jackson, Tennessee, United States

Site Status

Amarillo Center for Clinical Research

Amarillo, Texas, United States

Site Status

Accurate Clinical Management

Baytown, Texas, United States

Site Status

Dr. Dhiman Basu Private Practice

Colleyville, Texas, United States

Site Status

Metroplex Clinical Research Center

Dallas, Texas, United States

Site Status

Precision Comprehensive Clinical Research Solutions

Fort Worth, Texas, United States

Site Status

Rheumatology Center of Houston

Houston, Texas, United States

Site Status

Accurate Clinical Research

Houston, Texas, United States

Site Status

Southwest Rheumatology, P.A.

Mesquite, Texas, United States

Site Status

Accurate Clinical Research, Inc.

San Antonio, Texas, United States

Site Status

Univ of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status

Arthritis Clinic Of Central Texas

San Marcos, Texas, United States

Site Status

Spectrum Medical Inc.

Danville, Virginia, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

Rheumatic Disease Center

Glendale, Wisconsin, United States

Site Status

Emeritus Research

Botany, New South Wales, Australia

Site Status

The Rheumatology Research Unit Sunshine Coast

Maroochydore, Queensland, Australia

Site Status

Emeritus Research

Camberwell, Victoria, Australia

Site Status

Monash Medical Centre

Clayton, Victoria, Australia

Site Status

St Vincents Hospital Melbourne

Fitzroy, Victoria, Australia

Site Status

Griffith University

Southport, , Australia

Site Status

Ordensklinikum Linz GmbH Elisabethinen

Linz, Upper Austria, Austria

Site Status

Medizinische Universität Graz

Graz, , Austria

Site Status

Klinik Hietzing

Vienna, , Austria

Site Status

Cliniques Universitaires Saint-Luc

Brussels, Brussels Capital, Belgium

Site Status

UZ Leuven

Leuven, Vlaams Brabant, Belgium

Site Status

CHU de Liège

Liège, , Belgium

Site Status

SER - Serviços Especializados em Reumatologia da Bahia S/S - ME

Salvador, Estado de Bahia, Brazil

Site Status

CIP-Centro Internacional de Pesquisa

Goiânia, Goiás, Brazil

Site Status

Santa Casa de Misericordia de Belo Horizonte

Belo Horizonte, Minas Gerais, Brazil

Site Status

Centro de Estudos em Terapias Inovadoras-CETI

Curitiba, Paraná, Brazil

Site Status

EDUMED - Educação em Saúde Ltda.

Curitiba, Paraná, Brazil

Site Status

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

LMK Serviços Médicos S/S

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Hospital de Clinicas UNICAMP

Campinas, São Paulo, Brazil

Site Status

Oncovida- Centro de Onco-Hematologia de Mato Grosso

Cuiabá, , Brazil

Site Status

Hospital Alemao Oswaldo Cruz

São Paulo, , Brazil

Site Status

The First Affliated Hospital of Soochow University

Suzhou, China, China

Site Status

First affiliated Hospital of Sun Yat-Sen University

Guangzhou, Guangdong, China

Site Status

First Affiliated Hospital of the Harbin Medical University

Harbin, Heilongjiang, China

Site Status

The First Affiliated Hospital of Zhengzhou Universtiy

Zhengzhou, Henan, China

Site Status

Wuhan Union Hospital

Wuhan, Hubei, China

Site Status

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

Nanjing, Jiangsu, China

Site Status

Jiangxi Pingxiang People's Hospital

Pingxiang, Jiangxi, China

Site Status

China-Japan Union Hospital of Jilin University

Changchun, Jilin, China

Site Status

Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Site Status

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

Site Status

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

Ningbo First Hospital

Ningbo, Zhejiang, China

Site Status

Peking University First Hospital

Beijing, , China

Site Status

Beijing Peking Union Medical College Hospital

Beijing, , China

Site Status

Shanghai Huashan Hospital Affil to Fu Dan University

Shanghai, , China

Site Status

China Medical University (CMU) - First Affiliated Hospital

Shenyang, , China

Site Status

People's Hospital of Xinjiang Uygur Autonomous Region

Ürümqi, , China

Site Status

Klinicki Bolnicki Centar Rijeka

Rijeka, , Croatia

Site Status

University Hospital Split

Split, , Croatia

Site Status

Clinical Hospital Dubrava

Zagreb, , Croatia

Site Status

Revmatologicky ustav

Prague, Praha, Hlavní Mešto, Czechia

Site Status

Revmatologie.s.r.o.

Brno, , Czechia

Site Status

Fakultni nemocnice Olomouc

Olomouc, , Czechia

Site Status

ARTHROHELP s.r.o.

Pardubice, , Czechia

Site Status

Vseobecna fakultni nemocnice

Prague, , Czechia

Site Status

Universitätsklinikum Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Site Status

Universitätsklinikum Tübingen

Tübingen, Baden-Wurttemberg, Germany

Site Status

Klinikum der Universität München

München, Bavaria, Germany

Site Status

Universitätsklinikum Würzburg A. ö. R.

Würzburg, Bavaria, Germany

Site Status

Universitätsklinikum Köln

Cologne, North Rhine-Westphalia, Germany

Site Status

Universitatsmedizin der Johannes Gutenberg-Universitat Mainz

Mainz, Rhineland-Palatinate, Germany

Site Status

Universitätsklinikum Carl Gustav Carus

Dresden, Saxony, Germany

Site Status

Universität Leipzig - Universitätsklinikum

Leipzig, Saxony, Germany

Site Status

Charité Universitätsmedizin Berlin Campus Buch

Berlin, , Germany

Site Status

Immanuel Krankenhaus Rheuma Klinik Berlin Buch

Berlin, , Germany

Site Status

Schlosspark Klinik

Berlin, , Germany

Site Status

Gen Hospital of Athens G Gennimatas

Athens, Attica, Greece

Site Status

University General Hospital of Heraklion

Heraklion, Crete, Greece

Site Status

University General Hospital of Larissa

Larissa, , Greece

Site Status

Euromedica Kyanous Stavros General Hospital

Thessaloniki, , Greece

Site Status

Hippokration University Hopsital

Thessaloniki, , Greece

Site Status

Bekes Megyei Pandy Kalman Korhaz

Gyula, Bekes County, Hungary

Site Status

Vital Medical Center

Veszprém, Veszprém City, Hungary

Site Status

Budai Irgalmasrendi Korhaz

Budapest, , Hungary

Site Status

Qualiclinic Kft

Budapest, , Hungary

Site Status

Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointeze

Budapest, , Hungary

Site Status

Debreceni Egyetem Klinikai Kozpont Reumatologiai Tanszek

Debrecen, , Hungary

Site Status

Debreceni Egyetem Klinikai Kozpont

Debrecen, , Hungary

Site Status

Pecsi Tudomanyegyetem Klinikai Kozpont

Pécs, , Hungary

Site Status

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika

Szeged, , Hungary

Site Status

Vita Verum Egeszsegugyi Szolgaltato Bt

Székesfehérvár, , Hungary

Site Status

Meir Medical Center

Kfar Saba, , Israel

Site Status

Chaim Sheba Medical Center

Ramat Gan, , Israel

Site Status

Carmel Hospital

Haifa, Ḥeifā, Israel

Site Status

CIMAB SA de CV

Torreón, Coahuila, Mexico

Site Status

Morales Vargas Centro de Investigacion, S.C.

León, Guanajuato, Mexico

Site Status

Centro Integral en Reumatologia SA de CV

Guadalajara, Jalisco, Mexico

Site Status

Clinica de Investigacion en Reumatologia y Obesidad S. C.

Guadalajara, Jalisco, Mexico

Site Status

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

Guadalajara, Jalisco, Mexico

Site Status

Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.

Zapopan, Jalisco, Mexico

Site Status

Cliditer Sa de CV

Mexico City, Mexico City, Mexico

Site Status

Hospital Angeles Lindavista

Mexico City, Mexico City, Mexico

Site Status

Centro Peninsular de Investigacion S.C.P

Mérida, Yucatán, Mexico

Site Status

Köhler & Milstein Research

Mérida, Yucatán, Mexico

Site Status

Cemdeicy S.C.P.

Mérida, Yucatán, Mexico

Site Status

Clinosar Mexico S.A. de C.V

Mexico City, , Mexico

Site Status

Centro de Investigación y Tratamiento Reumatológico S.C

Mexico City, , Mexico

Site Status

Centro de Alta Especialidad Reumatologia e Inv Potosi, S.C.

San Luis Potosí City, , Mexico

Site Status

Medische Centrum Leeuwarden

Leeuwarden, Provincie Friesland, Netherlands

Site Status

Vrije Universiteit Medisch Centrum Amsterdam

Amsterdam, , Netherlands

Site Status

LLC MK Med

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

Chelyabinsk Regional Clinical Hospital

Chelyabinsk, , Russia

Site Status

City Hospital # 7

Kazan', , Russia

Site Status

Regional Clinical Hospital

Kursk, , Russia

Site Status

Russian State Medical University

Moscow, , Russia

Site Status

City Clinical Hospital 1 named after N.I. Pirogov

Moscow, , Russia

Site Status

Rheumatology Institute RAMS

Moscow, , Russia

Site Status

Healthy Family

Novosibirsk, , Russia

Site Status

Reafan

Novosibirsk, , Russia

Site Status

Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Medical Sciences

Novosibirsk, , Russia

Site Status

Regional Hospital - Omsk

Omsk, , Russia

Site Status

Orenburg State Medical Academy of Roszdrav

Orenburg, , Russia

Site Status

Ryazan State Medical University

Ryazan, , Russia

Site Status

Russian Medical Military Academy n.a. S.M. Kirov

Saint Petersburg, , Russia

Site Status

Departmental Hospital at Smolensk Station "rzhd" JSC

Smolensk, , Russia

Site Status

Kuvatov Republican Clinical Hospital

Ufa, , Russia

Site Status

Universitätsspital Basel

Basel, Canton of Basel-City, Switzerland

Site Status

Cantonal Hospital St.Gallen

Sankt Gallen, Canton of St. Gallen, Switzerland

Site Status

Chang Gung Memorial Hospital - Linkou

Kuei Shan Hsiang, Taoyuan Hsien, Taiwan

Site Status

Hualien Tzu-Chi Hospital

Dalin Township, , Taiwan

Site Status

Kaohsiung Veterans General Hospital

Kaohsiung City, , Taiwan

Site Status

Chang Gung Memorial Hospital - Kaohsiung Branch

Kaohsiung City, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

Site Status

Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status

Chi-Mei Medical Center

Tainan City, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Taipei Medical University Hospital

Taipei, , Taiwan

Site Status

Maidstone Hospital

Maidstone, Kent, United Kingdom

Site Status

Whipps Cross University Hospital

London, Surrey, United Kingdom

Site Status

Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust

Doncaster, , United Kingdom

Site Status

Guy's Hospital

London, , United Kingdom

Site Status

St. George's University Hospitals NHS Foundation Trust

London, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Brazil China Croatia Czechia Germany Greece Hungary Israel Mexico Netherlands Russia Switzerland Taiwan United Kingdom

References

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Yin J, Hou Y, Wang C, Qin C. Clinical outcomes of baricitinib in patients with systemic lupus erythematosus: Pooled analysis of SLE-BRAVE-I and SLE-BRAVE-II trials. PLoS One. 2025 Apr 30;20(4):e0320179. doi: 10.1371/journal.pone.0320179. eCollection 2025.

Reference Type DERIVED
PMID: 40305472 (View on PubMed)

Morand EF, Vital EM, Petri M, van Vollenhoven R, Wallace DJ, Mosca M, Furie RA, Silk ME, Dickson CL, Meszaros G, Jia B, Crowe B, de la Torre I, Dorner T. Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-I). Lancet. 2023 Mar 25;401(10381):1001-1010. doi: 10.1016/S0140-6736(22)02607-1. Epub 2023 Feb 24.

Reference Type DERIVED
PMID: 36848918 (View on PubMed)

Hannon CW, McCourt C, Lima HC, Chen S, Bennett C. Interventions for cutaneous disease in systemic lupus erythematosus. Cochrane Database Syst Rev. 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2.

Reference Type DERIVED
PMID: 33687069 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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https://trials.lillytrialguide.com/en-US/trial/64a5deI4M0sSScwYIMISsI

A Study of Baricitinib (LY3009104) in Participants With Systemic Lupus Erythematosus

Other Identifiers

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I4V-MC-JAHZ

Identifier Type: OTHER

Identifier Source: secondary_id

2017-005026-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

16676

Identifier Type: -

Identifier Source: org_study_id

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