Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

NCT ID: NCT03612206

Last Updated: 2018-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

113 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2018-04-01

Brief Summary

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Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Detailed Description

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Conditions

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Critical Illness Enteral Nutrition Inflammation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission
* age more than 18 years
* Acute Physiology and Chronic Health Evaluation II (APACHE II) score \>8

Exclusion Criteria

* not expected to survive 24 hours
* pregnancy
* any terminal stage disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanjing PLA General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Gao Tao

Research Assistant

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Tao G, Min-Hua C, Feng-Chan X, Yan C, Ting S, Wei-Qin L, Wen-Kui Y. Changes of plasma acetylcholine and inflammatory markers in critically ill patients during early enteral nutrition: A prospective observational study. J Crit Care. 2019 Aug;52:219-226. doi: 10.1016/j.jcrc.2019.05.008. Epub 2019 May 10.

Reference Type DERIVED
PMID: 31108325 (View on PubMed)

Other Identifiers

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2016NLYZDRC022

Identifier Type: -

Identifier Source: org_study_id

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