Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage

NCT ID: NCT03604276

Last Updated: 2024-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-12-01

Study Completion Date

2026-01-01

Brief Summary

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The purpose of this study is to determine the relationship between the Neuroinflammatory response and headache pain after subarachnoid hemorrhage.

Detailed Description

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Persistent headache is a significant medical issue that affects 20% of patients who survive an aneurysmal subarachnoid hemorrhage (SAH). This headache may last years, severely affecting quality of life. Laboratory evidence suggests that the persistent headache may be a result of a maladaptive neuroinflammatory response to the hemorrhage injury that is more vigorous than necessary. The goal of this study is to measure key immunomodulators in the blood and the cerebrospinal fluid of these patients in order to determine the magnitude and dynamics of their neuroinflammatory response. In addition, the investigators will collect and analyze observational data about the success of medications to treat headache, with a specific focus on the anti-inflammatory agent dexamethasone, in managing acute headache pain and preventing the development of persistent headaches in patients after SAH.

Conditions

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Subarachnoid Hemorrhage, Aneurysmal Headache Subarachnoid Hemorrhage

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Non-traumatic subarachnoid hemorrhage
* Age \> 18 years
* Treated with external ventricular drainage

Exclusion Criteria

* Pregnancy or lactation
* Age \< 18 years
* Traumatic SAH
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MaineHealth

OTHER

Sponsor Role lead

Responsible Party

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Elizabeth Glisic

Clinical Pharmacist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elizabeth K Glisic, PharmD

Role: PRINCIPAL_INVESTIGATOR

MaineHealth

Locations

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Maine Medical Center

Portland, Maine, United States

Site Status

Countries

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United States

Other Identifiers

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1100316-599

Identifier Type: -

Identifier Source: org_study_id

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