Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia

NCT ID: NCT03592290

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-15

Study Completion Date

2027-01-31

Brief Summary

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To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

Detailed Description

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The primary aim of this research is to identify the most robust site for monitoring hypovolemia as well as assess changes in peripheral waveforms monitored by the pulse oximeter collected from different sites (finger, ear, forehead, and nose), blood pressure, cerebral oximetry and peripheral venous pressure during gradual hypovolemia induced by lower body negative pressure (LBNP) in healthy volunteers.

Conditions

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Hypovolemia Hemodynamic Instability

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Interventions

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Lower body negative pressure

We will be monitoring the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

\* Healthy volunteers aged 20-45 with

Exclusion Criteria

* Pregnant women
* Under 20 years of age
* Subjects with coronary artery disease, diabetes, epilepsy and hypertension
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Yale University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Aymen Alian, MD

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

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John B. Pierce Laboratory

New Haven, Connecticut, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Aymen Alian, MD

Role: CONTACT

203-785-2802

Facility Contacts

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Aymen A Alian

Role: primary

203-785-2802

Other Identifiers

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000

Identifier Type: OTHER

Identifier Source: secondary_id

2000020057

Identifier Type: -

Identifier Source: org_study_id

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