Treatment of Chronic Postherpetic Pain With Fat Grafting
NCT ID: NCT03584061
Last Updated: 2021-02-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2018-05-01
2019-06-01
Brief Summary
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Detailed Description
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Clinically the condition is characterized by a painful, unilateral, vesicular rash. Pain is the most prominent symptom in around 90% of patients. In 10% of patients this pain remains and becomes chronic.
Post-herpetic neuralgia is a chronic pain syndrome that occurs after the dermal manifestations disappears.
Treatment is complex and mainly topical or systemic. For many patients this is not sufficient and they live with constant pain.
Fat grafting has shown promise in treating several different painful conditions such as post mastectomy pain syndrome, painful scars etc.
This study investigates is PHN can be treated by fat grafting.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Fat grafting/fat transplant.
Each patient receives fat grafting to the site of dermal pain. Fat is to be harvested for either the abdomen or the thigh.
Fat grafting
The area of dermal pain is identified and marked prior to surgery. The surgery starts with liposuction, either on the abdomen or the thigh. The harvested fat is prepared for fat grafting by sedimenting it for 10 minutes. The fat is then injected into the painful area, marked pre-surgery.
Interventions
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Fat grafting
The area of dermal pain is identified and marked prior to surgery. The surgery starts with liposuction, either on the abdomen or the thigh. The harvested fat is prepared for fat grafting by sedimenting it for 10 minutes. The fat is then injected into the painful area, marked pre-surgery.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Pain in area of former VZV-infection.
* Pain present over 3 months after reactivation of VZV and is present at least 4 days a week and of intensity \>3 on the VAS-scale.
Exclusion Criteria
* Other indication for fat grafting than pain.
18 Years
100 Years
ALL
Yes
Sponsors
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Odense University Hospital
OTHER
Responsible Party
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Martin Sollie
Principal investigator, M.D, Dept. of Plastic and Reconstructive Surgery
Principal Investigators
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Jens A Sørensen, MD. PhD.
Role: PRINCIPAL_INVESTIGATOR
Professor
Locations
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Odense University Hospital
Odense, Funen, Denmark
Countries
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References
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Sollie M, Thomsen JB, Sorensen JA. Autologous fat grafting seems to alleviate postherpetic neuralgia - a feasibility study investigating patient-reported levels of pain. J Plast Reconstr Aesthet Surg. 2021 Feb;74(2):350-356. doi: 10.1016/j.bjps.2020.08.038. Epub 2020 Aug 21.
Sollie M, Sorensen JA. Treatment of chronic post-herpetic neuralgia with autologous fat grafts: a first-in-the-world case report. Br J Pain. 2019 Nov;13(4):239-243. doi: 10.1177/2049463718817570. Epub 2018 Nov 28.
Other Identifiers
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S-20180007
Identifier Type: -
Identifier Source: org_study_id
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