Methadone in Post-Herpetic Neuralgia Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

1998-01-31

Study Completion Date

2013-03-31

Brief Summary

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Neuropathic pain is a common condition and affecting 40 to 70% of the general population. Post-herpetic neuralgia is a condition almost complex and requires a multi modal treatment. Aim: This is a pilot proof-of-principle study designed to evaluate the use of low-dose methadone in post-herpetic neuralgia patients who remained refractory after first and second line treatment for post-herpetic neuralgia (PHN) and had indication for the association of an opioid agent to their current drug regimen.

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Detailed Description

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Conditions

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Post-herpetic Neuralgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Methadone

in this arm patients will take methadone 5mg.

Group Type EXPERIMENTAL

Methadone

Intervention Type DRUG

patients with post-herpetic neuralgia take methadone or placebo to treat pain symptoms.

Placebo

in this arm patients will take placebo pills.

Group Type EXPERIMENTAL

Placebo

Intervention Type DRUG

patients with post-herpetic neuralgia take placebo to treat the pain symptoms.

Interventions

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Methadone

patients with post-herpetic neuralgia take methadone or placebo to treat pain symptoms.

Intervention Type DRUG

Placebo

patients with post-herpetic neuralgia take placebo to treat the pain symptoms.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with chronic (\>6 months) symptomatic PHN
* with visual analogical scale \>40/100mm
* use of first and second line drugs (tricyclic antidepressants, venlafaxine and gabapentinoids)