A 2 Week Study of Topical KD7040 in the Treatment of Postherpetic Neuralgia (PHN)

NCT ID: NCT00576108

Last Updated: 2008-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2008-07-31

Brief Summary

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This study will evaluate the safety and efficacy of 2 weeks of topical KD7040 versus placebo in the treatment of postherpetic neuralgia.

Detailed Description

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Conditions

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Postherpetic Neuralgia Shingles Herpes Zoster Neuropathic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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KD7040 topical gel

Group Type EXPERIMENTAL

KD7040 Topical Gel

Intervention Type DRUG

KD7040 topical gel

Placebo gel

Group Type PLACEBO_COMPARATOR

Placebo gel

Intervention Type DRUG

Placebo gel

Interventions

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KD7040 Topical Gel

KD7040 topical gel

Intervention Type DRUG

Placebo gel

Placebo gel

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female subjects ages 18-85 years
* Previous diagnosis of Shingles (Herpes Zoster) with pain persisting for at least 3 months, but not longer than 5 years, after healing of rash
* Subject with intact skin in the targeted treatment area
* Female subjects of childbearing potential must have a negative serum pregnancy test at screening, a negative urine human chorionic gonadotropin (hCG) test prior to randomization, and must use medically acceptable methods of birth control. All subjects must agree to take every precaution to ensure that pregnancy will not occur during the study.
* Subject must be willing and able to complete screening and study procedures as described int he protocol.
* Subject must voluntarily provide written Informed Consent prior to participation.

Exclusion Criteria

* Subjects with known hypersensitivity to KD7040 or methylparaben, or previous exposure to KD7040.
* Subjects pregnant, nursing or planning to become pregnant.
* Subjects who are immunocompromised or have clinically significant hematological abnormalities.
* Subjects with system dermatological conditions (e.g., psoriasis, atopic dermatitis) or impaired wound healing.
* Subjects who have had local anesthetic nerve blocks within 48 hours of study entry.
* Subjects having other sever pain which may confound assessment of PHN.
* Subjects who have serious, unstable, or clinically significant medical or psychological conditions, which, in the opinion of the Investigator(s) would compromise the subjects' participation in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kalypsys, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Kalypsys, Inc.

Locations

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United Bioscience Corporation

Kansas City, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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KD7040-NP02

Identifier Type: -

Identifier Source: org_study_id